Influence of patterned titanium coatings on polarization of macrophage and osteogenic differentiation of bone marrow stem cells
文献类型：期刊论文
| 作者 | Zhang, Zequan1; Xie, Youtao; Pan, Houhua; Huang, Liping; Zheng, Xuebin |
| 刊名 | JOURNAL OF BIOMATERIALS APPLICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 32期号:7页码:977 |
| 关键词 | Osteoimmunomodulatory properties macrophage E-cadherin pattern titanium coating |
| ISSN号 | 0885-3282 |
| DOI | 10.1177/0885328217746802 |
| 英文摘要 | Biomaterial surface topography plays a vital role in the osteointegration of implants by regulating the early cell responses and tissue growth-in. However, most of the previous researches focused on the effects of osteogenic cells, only a little is known about the immune cells which dominate osteogenesis after implanting. In this paper, patterned titanium coatings were fabricated and the effects of surface topography on the macrophage behaviors were investigated. On patterned titanium surface, macrophages preferred to polarize to M2, while macrophages on traditional titanium coatings presented higher M1 polarization. Nearly 70% higher expression of anti-inflammatory genes, including interleukin-4, interleukin-10, interleukin-1ra, and arginase, were detected on the patterned titanium coatings. While the pro-inflammatory genes, such as interleukin-1, interleukin-6, tumor necrosis factor-, interferon-, and inducible nitric oxide synthase were notably depressed. Up-regulation of the osteoinductive cytokines were also detected on the patterned coatings, which indicated advantageous osteogenic microenvironment provided by macrophages. Immunomodulation effect on osteogenesis was also investigated in this study. Stimulated with RAW cells/patterned coatings conditioned medium, bone marrow stem cells presented nearly 1.5 fold higher expression of osteogenic genes and more mineralization nodules than the traditional sprayed Ti coatings. All these results suggested that modulating materials with a patterned surface might be a valuable strategy to endow the implants with favorable osteoimmunomodulatory properties. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000419897400013 |
| 出版者 | SAGE PUBLICATIONS LTD |
| 资助机构 | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the National Natural Science Foundation of China (Grant No. 51502328). ; The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the National Natural Science Foundation of China (Grant No. 51502328). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24519]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zequan,Xie, Youtao,Pan, Houhua,et al. Influence of patterned titanium coatings on polarization of macrophage and osteogenic differentiation of bone marrow stem cells[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2018,32(7):977, 986. |
| APA | Zhang, Zequan,Xie, Youtao,Pan, Houhua,Huang, Liping,&Zheng, Xuebin.(2018).Influence of patterned titanium coatings on polarization of macrophage and osteogenic differentiation of bone marrow stem cells.JOURNAL OF BIOMATERIALS APPLICATIONS,32(7),977. |
| MLA | Zhang, Zequan,et al."Influence of patterned titanium coatings on polarization of macrophage and osteogenic differentiation of bone marrow stem cells".JOURNAL OF BIOMATERIALS APPLICATIONS 32.7(2018):977. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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