SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy
文献类型：期刊论文
| 作者 | Zhang, Meng1; Cui, Zhaowen; Song, Ruixue2; Lv, Bin3; Tang, Zhongmin1; Meng, Xianfu2; Chen, Xiaoyan2; Zheng, Xiangpeng3; Zhang, Jiawen4; Yao, Zhenwei4 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 155页码:135 |
| ISSN号 | 0142-9612 |
| 关键词 | Tin tungstate Photodynamic therapy Efficiency Radiotherapy Tumor |
| DOI | 10.1016/j.biomaterials.2017.11.013 |
| 英文摘要 | The "partial matching" between upconversion nanoparticle (UCNP) emission and absorption by photosensitizers (PSs) often leads to a theoretically reduced therapeutic efficiency in UC-based photodynamic therapy (PDT) strategies in which the chosen PSs have limited capabilities and are unable to utilize all the near-infrared-upconverted light. In this study, needle-like SnWO4 nanocrystals (SWs) with a broad UV-vis absorption region were synthesized to solve the problem. After covalent conjugation with UCNPs, all the UCNP-emitted light was effectively absorbed by SWs, triggering the type-I PDT process to activate ROS maxima. The unique nanostructure of the as-formed UCNP-SnWO4 nanohybrids (USWs) also enhanced the receiving light intensities of SW, which further boosted the antitumor efficacy. Meanwhile, the strong X-ray attenuation capacity of both tungsten and tin elements qualified the USWs as excellent radio-sensitizers for radiotherapy (RT) enhancement, which played a complementary role with PDT treatment because PDT-mediated induction arrested the cells in the G0-G1 cell cycle phase, and RT was more damaging toward cells in the G2/M phase. The remarkably enhanced UC-PDT/RT efficiency of USWs was next validated in vitro and in vivo, and the combined NIR light and ionizing irradiation treatment completely suppressed tumor growth, revealing its great potential as an efficient anticancer therapeutic agent against solid tumors. (C) 2017 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000419539000012 |
| 资助机构 | The author would be greatly acknowledge the financial support from the China National Funds for Distinguished Young Scientists (Grant No. 51725202), the National Natural Science Foundation of China (Grant No. 51372260, 81472794, 81671732), and the Shanghai Excellent Academic Leaders Program (Grant No.16XD1404000). ; The author would be greatly acknowledge the financial support from the China National Funds for Distinguished Young Scientists (Grant No. 51725202), the National Natural Science Foundation of China (Grant No. 51372260, 81472794, 81671732), and the Shanghai Excellent Academic Leaders Program (Grant No.16XD1404000). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24522]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China 4.Fudan Univ, Huadong Hosp, Dept Radiat Oncol, Shanghai 200040, Peoples R China 5.Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai 200040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Meng,Cui, Zhaowen,Song, Ruixue,et al. SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy[J]. BIOMATERIALS,2018,155:135, 144. |
| APA | Zhang, Meng.,Cui, Zhaowen.,Song, Ruixue.,Lv, Bin.,Tang, Zhongmin.,...&Bu, Wenbo.(2018).SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy.BIOMATERIALS,155,135. |
| MLA | Zhang, Meng,et al."SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy".BIOMATERIALS 155(2018):135. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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