Theranostic 2D Tantalum Carbide (MXene)
文献类型：期刊论文
| 作者 | Lin, Han1; Wang, Youwei; Gao, Shanshan1; Chen, Yu; Shi, Jianlin |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:4 |
| 关键词 | dual-mode imaging nanosheets photothermal therapy tantalum carbide theranostic |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201703284 |
| 英文摘要 | The large-dimensional and rigid ceramic bulks fabricated by high-temperature solid-phase reaction and sintering have never been considered for possibly entering and circulating within the blood vessels for biomedical applications, especially on combating cancer. Here, it is reported for the first time that MAX ceramic biomaterials exhibit unique functionalities for dual-mode photoacoustic/computed tomography imaging and are highly effective for in vivo photothermal ablation of tumors upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene). As a paradigm, 2D ultrathin tantalum carbide nanosheets (Ta4C3 MXenes) with nanosized lateral sizes are successfully synthesized based on a two-step liquid exfoliation strategy of MAX phase Ta4AlC3 by combined hydrofluoric acid (HF) etching and probe sonication. The structural, electronic, and surface characteristics of the as-exfoliated nanosheets are revealed by various characterizations combined with first-principles calculations via density functional theory. Especially, the superior photothermal-conversion performance (efficiency. of 44.7%) and in vitro/in vivo photothermal ablation of tumor by biocompatible soybean phospholipid-modified Ta4C3 nanosheets are systematically revealed and demonstrated. Based on the large family members of MXenes, this work may offer a paradigm that MXenes can achieve the specific biomedical applications (here, theranostic) providing that their compositions and nanostructures are carefully tuned and optimized to meet the strict requirements of biomedicine. |
| 学科主题 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| WOS记录号 | WOS:000422932800002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51672303, 51722211), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169), and Development Fund for Shanghai Talents (2015). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Fudan University. ; The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51672303, 51722211), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169), and Development Fund for Shanghai Talents (2015). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Fudan University. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24537]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Han,Wang, Youwei,Gao, Shanshan,et al. Theranostic 2D Tantalum Carbide (MXene)[J]. ADVANCED MATERIALS,2018,30(4). |
| APA | Lin, Han,Wang, Youwei,Gao, Shanshan,Chen, Yu,&Shi, Jianlin.(2018).Theranostic 2D Tantalum Carbide (MXene).ADVANCED MATERIALS,30(4). |
| MLA | Lin, Han,et al."Theranostic 2D Tantalum Carbide (MXene)".ADVANCED MATERIALS 30.4(2018). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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