Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair
文献类型：期刊论文
| 作者 | Sun, Tuan-Wei; Zhu, Ying-Jie; Chen, Feng2 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:46页码:26133 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra03972k |
| 英文摘要 | The synthetic bone grafts that mimic the composition and structure of human natural bone exhibit great potential for application in bone defect repair. In this study, a biomimetic porous nanocomposite consisting of ultralong hydroxyapatite nanowires (UHANWs) and collagen (Col) with 66.7 wt% UHANWs has been prepared by the freeze drying process and subsequent chemical crosslinking. Compared with the pure collagen as a control sample, the biomimetic UHANWs/Col porous nanocomposite exhibits significantly improved mechanical properties. More significantly, the rehydrated UHANWs/Col nanocomposite exhibits an excellent elastic behavior. Moreover, the biomimetic UHANWs/Col porous nanocomposite has a good degradable performance with a sustained release of Ca and P elements, and can promote the adhesion and spreading of mesenchymal stem cells. The in vivo evaluation reveals that the biomimetic UHANWs/Col porous nanocomposite can significantly enhance bone regeneration compared with the pure collagen sample. After 12 weeks implantation, the woven bone and lamellar bone are formed throughout the entire UHANWs/Col porous nanocomposite, and connect directly with the host bone to construct a relatively normal bone marrow cavity, leading to successful osteointegration and bone reconstruction. The as-prepared biomimetic UHANWs/Col porous nanocomposite is promising for applications in various fields such as bone defect repair. |
| 学科主题 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000441685100030 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | Financial support from the Science and Technology Commission of Shanghai Municipality (15JC1491001), the National Natural Science Foundation of China (51472259) is gratefully acknowledged. Authors thank Zhuyun Cai for the help with animal experiments. ; Financial support from the Science and Technology Commission of Shanghai Municipality (15JC1491001), the National Natural Science Foundation of China (51472259) is gratefully acknowledged. Authors thank Zhuyun Cai for the help with animal experiments. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24564]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.[Sun, Tuan-Wei 2.Zhu, Ying-Jie 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tuan-Wei,Zhu, Ying-Jie,Chen, Feng. Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair[J]. RSC ADVANCES,2018,8(46):26133, 26144. |
| APA | Sun, Tuan-Wei,Zhu, Ying-Jie,&Chen, Feng.(2018).Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair.RSC ADVANCES,8(46),26133. |
| MLA | Sun, Tuan-Wei,et al."Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair".RSC ADVANCES 8.46(2018):26133. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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