Ultrathin Cu-TCPP MOF nanosheets: a new theragnostic nanoplatform with magnetic resonance/near-infrared thermal imaging for synergistic phototherapy of cancers
文献类型：期刊论文
| 作者 | Li, Bo; Wang, Xiaoya; Chen, Lei; Zhou, Yanling; Dang, Wentao; Chang, Jiang; Wu, Chengtie |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:15页码:4086 |
| 关键词 | metal-organic frameworks Cu-TCPP nanosheets imaging phototherapy |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.25433 |
| 英文摘要 | Nanostructures based on metal-organic frameworks (MOFs) have promising potential as theragnostic nanoplatforms for phototherapy of cancer cells. However, the MOFs alone are seldom reported to be used as photothermal agents mainly due to their poor near-infrared (NIR) light absorption. Methods: Ultrathin copper-tetrakis (4-carboxyphenyl) porphyrin (Cu-TCPP) MOF nanosheets were prepared by a facile solvothermal route. The photothermal therapy (PTT), photodynamic therapy (PDT), and T-1-weighted magnetic resonance (MR) imaging capabilities and the high biocompatibility of these composite nanosheets were evaluated in vitro as well as in vivo in a mouse tumor model. Results: The ultrathin Cu-TCPP MOF nanosheets exhibited 1) strong NIR absorption because of the d-d energy band transition of Cu2+ and the ultrathin characteristic translating into excellent photothermal performance, 2) ability to produce singlet oxygen because of the inherent characteristic of TCPP, and 3) capability for MR imaging because of the unpaired 3d electrons of copper. Conclusion: Our study demonstrated that the Cu-TCPP MOF nanosheets are a promising phototherapy nanoplatform with the synergistic ability for PTT and PDT of cancer, guided by MR and infrared thermal imaging. |
| 学科主题 | Medicine, Research & Experimental |
| WOS记录号 | WOS:000440377100006 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | B. Li, and X. Y. Wang contributed equally to this work. The authors appreciate support from the National Key Research and Development Program of China (2017YFB0702602-02, 2017YFB0702602), the Natural Science Foundation of China (51702348 and 81771989), Shanghai Sailing Program (17YF1421400, 17540712300), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201705), Postdoctoral Science Foundation of China (2017M610260) and Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018285). ; B. Li, and X. Y. Wang contributed equally to this work. The authors appreciate support from the National Key Research and Development Program of China (2017YFB0702602-02, 2017YFB0702602), the Natural Science Foundation of China (51702348 and 81771989), Shanghai Sailing Program (17YF1421400, 17540712300), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201705), Postdoctoral Science Foundation of China (2017M610260) and Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018285). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24565]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Bo,Wang, Xiaoya,Chen, Lei,et al. Ultrathin Cu-TCPP MOF nanosheets: a new theragnostic nanoplatform with magnetic resonance/near-infrared thermal imaging for synergistic phototherapy of cancers[J]. THERANOSTICS,2018,8(15):4086, 4096. |
| APA | Li, Bo.,Wang, Xiaoya.,Chen, Lei.,Zhou, Yanling.,Dang, Wentao.,...&Wu, Chengtie.(2018).Ultrathin Cu-TCPP MOF nanosheets: a new theragnostic nanoplatform with magnetic resonance/near-infrared thermal imaging for synergistic phototherapy of cancers.THERANOSTICS,8(15),4086. |
| MLA | Li, Bo,et al."Ultrathin Cu-TCPP MOF nanosheets: a new theragnostic nanoplatform with magnetic resonance/near-infrared thermal imaging for synergistic phototherapy of cancers".THERANOSTICS 8.15(2018):4086. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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