A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy
文献类型：期刊论文
| 作者 | Zhou, Xiaohan; Wang, Longchen1; Xu, Yanjun1; Du, Wenxian2; Cai, Xiaojun1; Wang, Fengjuan; Ling, Yi1; Chen, Hangrong2; Wang, Zhigang; Hu, Bing1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:18页码:9812 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra00215k |
| 英文摘要 | To overcome the toxicity of chemotherapy, increasing attention has been paid to local drug delivery systems (DDSs). pH-Sensitive hydrogels have emerged as promising DDS materials in the biomedical field due to their remarkable characteristics. However, the pH environment in tumor varies from person to person, which makes the applicability of systems based on pH challenging. In this study, we developed a contractible hydroxypropyl methyl cellulose (HPMC)/Fe3O4 hydrogel with dual-response pH and magnetic properties aiming to overcome the limitations of pH-sensitive hydrogel drug delivery systems and further increase their efficiency in tumor therapy. The HPMC/Fe3O4 hydrogel could act as a drug delivery system that combines pH-sensitive triggering and magnetic dual-response drug release for synergistic chemo-magnetic hyperthermia therapy. The drug delivery profile of the HPMC/Fe3O4/ doxorubicin hydrochloride (DOX) hydrogel was determined in vitro and revealed a remarkable pH-sensitive performance. After synergistic chemo-magnetic hyperthermia treatment, mice with 4T1 breast cancer xenografts recovered without any recurrence or metastasis, demonstrating the synergistic effect of chemotherapy and magnetic hyperthermia therapy. Meanwhile, reduced toxicity and superior anticancer effects were achieved due to the combined effect of the pH and magnetic hyperthermia response properties. This study demonstrated the high efficacy and low toxicity of the improved design of HPMC/Fe3O4 for drug delivery, which may provide a promising approach for the application of chemo-magnetic hyperthermia cancer therapy. |
| 学科主题 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000430451800028 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | The authors thank Prof. Yaopeng Zhang from DongHua University for help with this study. We acknowledge financial support from 973 project (2014CB744500), the National Science Foundation for Distinguished Young Scholars (NO. 81425014), the National Natural Science of China (NO. 81720108023, 31630026), and Shanghai Key Discipline of Medical Imaging (2017ZZ02005). ; The authors thank Prof. Yaopeng Zhang from DongHua University for help with this study. We acknowledge financial support from 973 project (2014CB744500), the National Science Foundation for Distinguished Young Scholars (NO. 81425014), the National Natural Science of China (NO. 81720108023, 31630026), and Shanghai Key Discipline of Medical Imaging (2017ZZ02005). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24577]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chongqing Med Univ, Affiliated Hosp 2, State Key Lab Ultrasound Engn Med Cofounded Chong, Chongqing Key Lab Ultrasound Mol Imaging,Minist S, Chongqing 400010, Peoples R China 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Xiaohan,Wang, Longchen,Xu, Yanjun,et al. A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy[J]. RSC ADVANCES,2018,8(18):9812, 9821. |
| APA | Zhou, Xiaohan.,Wang, Longchen.,Xu, Yanjun.,Du, Wenxian.,Cai, Xiaojun.,...&Zheng, Yuanyi.(2018).A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy.RSC ADVANCES,8(18),9812. |
| MLA | Zhou, Xiaohan,et al."A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy".RSC ADVANCES 8.18(2018):9812. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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