Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance Imaging-Guided Efficient Photothermal Ablation of Cancer
文献类型：期刊论文
| 作者 | Zhang, Liang; Sheng, Danli1; Wang, Dong; Yao, Yuanzhi2; Yang, Ke; Wang, Zhigang1; Deng, Liming1; Chen, Yu3 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:6页码:1591 |
| 关键词 | Melanin Liposome Photoacoustic imaging MRI Photothermal ablation Nanomedicine |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.22430 |
| 英文摘要 | Background: The construction of theranostic nanosystems with concurrently high biosafety and therapeutic performance is a challenge but has great significance for the clinical translation of nanomedicine for combating cancer. Methods: Bio-inspired melanin-based nanoliposomes (Lip-Mel) as theranostic agents were constructed for simultaneous photoacoustic (PA) imaging-and T-1-weighted magnetic resonance (MR) imaging-guided photothermal ablation of tumors, which was demonstrated both in vitro and in vivo. The high biosafety of Lip-Mel was also systematically evaluated. Results: The achieved Lip-Mel nanoliposomes demonstrated their imaging capability for both PA and T-1-weighted MR imaging (r(1) = 0.25 mM(-1)center dot s(-1)) both in vitro and in vivo, providing the potential for therapeutic guidance and monitoring. Importantly, the desirable photothermal-conversion efficiency of the as-prepared Lip-Mel achieved complete eradication of tumors in breast cancer-bearing mice, exhibiting remarkable photothermal-based therapeutic performance. In particular, the efficient encapsulation of melanin into the PEGylated liposome mitigated the potential toxicity of melanin and improved the photothermal performance of the loaded melanin. Systematic in vivo biosafety evaluations demonstrated the high biocompatibility of Lip-Mel at a high dose of 100 mg/ kg. Conclusion: In this work, we reported a bioinspired strategy where melanin, a natural product in the human body, is encapsulated into PEGylated nanoliposomes for efficient theranostics with high biocompatibility. This work provides a new strategy for creating desirable theranostic agents with concurrent high biocompatibility and satisfactory theranostic performance through the use of materials that totally originate from biosystems. |
| 学科主题 | Medicine, Research & Experimental |
| WOS记录号 | WOS:000424662800010 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant No. 81571688, 81771845, 81371718, 51722211, 51672303), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001) and Chongqing Foundation and Cutting-edge Research Projects (cstc2014jcyjA10013). ; We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant No. 81571688, 81771845, 81371718, 51722211, 51672303), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001) and Chongqing Foundation and Cutting-edge Research Projects (cstc2014jcyjA10013). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24591]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing 400016, Peoples R China 2.Chongqing Med Univ, Inst Ultrasound Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China 3.Chongqing Canc Hosp, Chongqing Canc Inst, Dept Ultrasound, Chongqing Canc Ctr, Chongqing 400030, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Liang,Sheng, Danli,Wang, Dong,et al. Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance Imaging-Guided Efficient Photothermal Ablation of Cancer[J]. THERANOSTICS,2018,8(6):1591, 1606. |
| APA | Zhang, Liang.,Sheng, Danli.,Wang, Dong.,Yao, Yuanzhi.,Yang, Ke.,...&Chen, Yu.(2018).Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance Imaging-Guided Efficient Photothermal Ablation of Cancer.THERANOSTICS,8(6),1591. |
| MLA | Zhang, Liang,et al."Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance Imaging-Guided Efficient Photothermal Ablation of Cancer".THERANOSTICS 8.6(2018):1591. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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