2D Superparamagnetic Tantalum Carbide Composite MXenes for Efficient Breast-Cancer Theranostics
文献类型：期刊论文
| 作者 | Liu, Zhuang1; Lin, Han2,3; Zhao, Menglong4; Dai, Chen5; Zhang, Shengjian1; Peng, Weijun1; Chen, Yu2 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:6页码:1648 |
| 关键词 | Tantalum carbide MXene Fe3O4 Multimodal imaging Photothermal therapy Nanomedicine |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.23369 |
| 英文摘要 | Background: The emergence of two-dimensional MXenes has spurred their versatile applications in broad fields, but the exploring of novel MXene-based family members and their potential applications in theranostic nanomedicine (concurrent diagnostic imaging and therapy) have been rarely explored. In this work, we report the construction of a novel superparamagnetic MXene-based theranostic nanoplatform for efficient breast-cancer theranostics, which was based on intriguing tantalum carbide (Ta4C3) MXene and its further rational surface-superparamagnetic iron-oxide functionalization (Ta4C3-IONP-SPs composite MXenes) for efficient breast-cancer theranostic. Methods: The fabrication of ultrathin Ta4C3 nanosheets was based on an exfoliation strategy and superparamagnetic iron oxide nanoparticles were in-situ grown onto the surface of Ta4C3 MXene according to the redox reaction of MXene. Ta4C3-IONP MXenes were modified with soybean phospholipid (SP) to guarantee high stability in physiological conditions. The photothermal therapy, contrast-enhanced CT, T-2-weighted magnetic resonance imaging and the high biocompatibility of these composite nanosheets have also been evaluated in vitro at cellular level and in vivo on mice breast tumor allograft tumor model. Results: The Ta component of Ta4C3-IONP-SPs exhibits high performance for contrast-enhanced CT imaging because of its high atomic number and high X-ray attenuation coefficient, and the integrated superparamagnetic IONPs act as excellent contrast agents for T-2-weighted magnetic resonance imaging. Especially, these Ta4C3-IONP-SPs composite nanosheets with high photothermal-conversion efficiency (eta: 32.5%) has achieved complete tumor eradication without reoccurrence, verifying their highly efficient breast-tumor photo-ablation performance. Conclusion: This work not only significantly broadens the biomedical applications of MXene-based nanoplatforms (Ta4C3 MXene) by exploring their novel family members and further functionalization strategies (magnetic functionalization in this work), but also provides a novel and efficient theranostic nanoplatform for efficient breast-cancer theranostics. |
| 学科主题 | Medicine, Research & Experimental |
| WOS记录号 | WOS:000424662800014 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant No. 51722211 and 51672303), Natural Science Foundation of Shanghai (15ZR1407700) and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). ; We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant No. 51722211 and 51672303), Natural Science Foundation of Shanghai (15ZR1407700) and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24592]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Fudan Univ, Dept Radiol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China 2.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Shanghai Med Coll, Shanghai Inst Med Imaging,Dept Radiol, Shanghai 200032, Peoples R China 6.Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Ultrasound Med, Shanghai 200072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhuang,Lin, Han,Zhao, Menglong,et al. 2D Superparamagnetic Tantalum Carbide Composite MXenes for Efficient Breast-Cancer Theranostics[J]. THERANOSTICS,2018,8(6):1648, 1664. |
| APA | Liu, Zhuang.,Lin, Han.,Zhao, Menglong.,Dai, Chen.,Zhang, Shengjian.,...&Chen, Yu.(2018).2D Superparamagnetic Tantalum Carbide Composite MXenes for Efficient Breast-Cancer Theranostics.THERANOSTICS,8(6),1648. |
| MLA | Liu, Zhuang,et al."2D Superparamagnetic Tantalum Carbide Composite MXenes for Efficient Breast-Cancer Theranostics".THERANOSTICS 8.6(2018):1648. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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