Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound
文献类型：期刊论文
| 作者 | Cao, Yang; Chen, Yuli; Yu, Tao; Guo, Yuan; Liu, Fengqiu; Yao, Yuanzhi; Li, Pan; Wang, Dong; Wang, Zhigang; Chen, Yu1 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:5页码:1327 |
| 关键词 | Programmable drug release Low-intensity focused ultrasound (LIFU) Perfluorocarbon nanodroplets Ultrasound imaging |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.21492 |
| 英文摘要 | Background: As one of the most effective triggers with high tissue-penetrating capability and non-invasive feature, ultrasound shows great potential for controlling the drug release and enhancing the chemotherapeutic efficacy. In this study, we report, for the first time, construction of a phase-changeable drug-delivery nanosystem with programmable low-intensity focused ultrasound (LIFU) that could trigger drug-release and significantly enhance anticancer drug delivery. Methods: Liquid-gas phase-changeable perfluorocarbon (perfluoropentane) and an anticancer drug (doxorubicin) were simultaneously encapsulated in two kinds of nanodroplets. By triggering LIFU, the nanodroplets could be converted into microbubbles locally in tumor tissues for acoustic imaging and the loaded anticancer drug (doxorubicin) was released after the microbubble collapse. Based on the acoustic property of shell materials, such as shell stiffness, two types of nanodroplets (lipid-based nanodroplets and PLGA-based nanodroplets) were activated by different acoustic pressure levels. Ultrasound irradiation duration and power of LIFU were tested and selected to monitor and control the drug release from nanodroplets. Various ultrasound energies were introduced to induce the phase transition and microbubble collapse of nanodroplets in vitro (3 W/3 min for lipid nanodroplets; 8 W/3 min for PLGA nanodroplets). Results: We detected three steps in the drug-releasing profiles exhibiting the programmable patterns. Importantly, the intratumoral accumulation and distribution of the drug with LIFU exposure were significantly enhanced, and tumor proliferation was substantially inhibited. Co-delivery of two drug-loaded nanodroplets could overcome the physical barriers of tumor tissues during chemotherapy. Conclusion: Our study provides a new strategy for the efficient ultrasound-triggered chemotherapy by nanocarriers with programmable LIFU capable of achieving the on-demand drug release. |
| 学科主题 | Medicine, Research & Experimental |
| WOS记录号 | WOS:000424515900010 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | This work was supported by the National Natural Science Foundation of China (81401503, 81630047, 81471713, 31630026, 81371578), China Postdoctoral Science Foundation funded projects (2015T80963, 2016M590869), National Key Research and Development Program of China (Grant No. 2016YFA0203700) and Chongqing Postdoctoral Science Foundation funded project (Xm2015089). ; This work was supported by the National Natural Science Foundation of China (81401503, 81630047, 81471713, 31630026, 81371578), China Postdoctoral Science Foundation funded projects (2015T80963, 2016M590869), National Key Research and Development Program of China (Grant No. 2016YFA0203700) and Chongqing Postdoctoral Science Foundation funded project (Xm2015089). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24594]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chongqing Med Univ, Inst Ultrasound Imaging, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Yang,Chen, Yuli,Yu, Tao,et al. Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound[J]. THERANOSTICS,2018,8(5):1327, 1339. |
| APA | Cao, Yang.,Chen, Yuli.,Yu, Tao.,Guo, Yuan.,Liu, Fengqiu.,...&Ran, Haitao.(2018).Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound.THERANOSTICS,8(5),1327. |
| MLA | Cao, Yang,et al."Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound".THERANOSTICS 8.5(2018):1327. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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