Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy
文献类型：期刊论文
| 作者 | Yao, Minghua; Ma, Ming1,2; Xu, Huixiong; Pan, Xiaoxia2; Xu, Guang; Wu, Rong |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:9页码:4514 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c7ra12074e |
| 英文摘要 | High intensity focused ultrasound (HIFU), as a promising and minimally invasive therapeutic modality against various solid tumors, has received considerable attention in the biomedical field. However, both the accuracy and efficacy of this technique are currently unsatisfactory. Herein, a nanometer-sized organic/inorganic hybrid enhancement agent for photoacoustic imaging (PAI)-guided HIFU therapy was designed and fabricated by concurrently encapsulating both Cu2-xS nanodots (NDs) and perfluorooctyl bromide (PFOB) into a poly(lactic-co-glycolic acid) PLGA nanocapsule (denoted CPPNs). These nanocapsules assumed a unique core/satellite/shell sandwich structure, and combined the merits of small and uniform particle size (about 120 nm), favorable biosafety, and multifunctional theranostic ability into one system. The high performance of Cu2-xS NDs in the absorption and conversion of near infrared laser confers high PAI contrast capability to the CPPNs, by which the location of the CPPNs within a tumor can be monitored successfully under PAI. Furthermore, our in vitro and in vivo results confirmed that the encapsulated PFOB in CPPNs increased the cavitation effect and thus enhanced the ablation efficacy under HIFU exposure. CPPNs show great potential as an efficient and powerful theranostic agent for future PAI-guided HIFU synergistic therapy. |
| 学科主题 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000423898000003 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | This work was supported by the National Natural Science Foundation of China [grant numbers 81601499, 51402329, 81471673 and 81671699]. The authors are grateful to Mr Qi Wang for his help with high intensity focused ultrasound (HIFU) experiment. ; This work was supported by the National Natural Science Foundation of China [grant numbers 81601499, 51402329, 81471673 and 81671699]. The authors are grateful to Mr Qi Wang for his help with high intensity focused ultrasound (HIFU) experiment. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24595]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Ultrasound Med, 301 Yanchangzhong Rd, Shanghai 200072, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 3.Fudan Univ, State Key Lab Mol Engn Polymers, 220 Handan Rd, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Minghua,Ma, Ming,Xu, Huixiong,et al. Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy[J]. RSC ADVANCES,2018,8(9):4514, 4524. |
| APA | Yao, Minghua,Ma, Ming,Xu, Huixiong,Pan, Xiaoxia,Xu, Guang,&Wu, Rong.(2018).Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy.RSC ADVANCES,8(9),4514. |
| MLA | Yao, Minghua,et al."Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy".RSC ADVANCES 8.9(2018):4514. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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