Nanosized Hollow Colloidal Organosilica Nanospheres with High Elasticity for Contrast-Enhanced Ultrasonography of Tumors
文献类型：期刊论文
| 作者 | Wang, Yi; Zhang, Kun1; Xua, Yong-Hua; Chen, Hang-Rong |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2018 |
| 卷号 | 4期号:1页码:248 |
| ISSN号 | 2373-9878 |
| 关键词 | ultrasound contrast agent mesoporous hollow silica nanoparticles perfluorohexane stability high elasticity |
| DOI | 10.1021/acsbiomaterials.7b00779 |
| 英文摘要 | Despite several reports on using silica hollow spheres as ultrasound contrast agents, they all suffer from their inherent drawbacks, e.g., poor imaging ability caused by highly rigid shell or large particles size that leads to failures of these particles in entering tumor tissues, no mesoporous channels to load other active molecules (e.g., fluorocarbons). In this report, amino groups-functionalized hollow colloidal organosilica nanospheres (HCONs) with approximately 260 nm in diameter are prepared. Depending on the thin and pure organosilica shell, the HCONs feature high elasticity beneficial for acquiring excellent ultrasonic imaging outcomes. Our in vitro experiment shows that the ultrasonic contrast increases 11 times and in vivo experiment also shows that the ultrasound imaging performance of tumor is improved for 1.5 times. More importantly, HCONs can load liquid perfluorohexane (PFH) capable of vaporizing into gas bubbles, which further enhance the ultrasonic imaging outcome. In addition, the organosilica nanospheres have a good biosafety, which is expected to become a new generation of ultrasound contrast agent. |
| 学科主题 | Materials Science, bioMaterials |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000422613800023 |
| 资助机构 | This work was supported by grants from National Natural Science Foundation of China (Grants 81771836 and 81501473), and grants from Guangxi Collaborative Innovation Center of Biomedicine (Grant GCICB-SR-201703). ; This work was supported by grants from National Natural Science Foundation of China (Grants 81771836 and 81501473), and grants from Guangxi Collaborative Innovation Center of Biomedicine (Grant GCICB-SR-201703). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24598]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chongqing Med Univ, Inst Ultrasound Engn Med, 1 Yi Xue Yuan Rd, Chongqing 400016, Peoples R China 2.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Med Ultrasound, 301 Yan Chang Zhong Rd, Shanghai 200072, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 4.Cent Hosp Xuhui Dist, Dept Imaging & Intervent Radiol, 966 Huai Hai Zhong Rd, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yi,Zhang, Kun,Xua, Yong-Hua,et al. Nanosized Hollow Colloidal Organosilica Nanospheres with High Elasticity for Contrast-Enhanced Ultrasonography of Tumors[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(1):248, 256. |
| APA | Wang, Yi,Zhang, Kun,Xua, Yong-Hua,&Chen, Hang-Rong.(2018).Nanosized Hollow Colloidal Organosilica Nanospheres with High Elasticity for Contrast-Enhanced Ultrasonography of Tumors.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(1),248. |
| MLA | Wang, Yi,et al."Nanosized Hollow Colloidal Organosilica Nanospheres with High Elasticity for Contrast-Enhanced Ultrasonography of Tumors".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.1(2018):248. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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