Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties
文献类型：期刊论文
| 作者 | Xu, Chen1; Wang, Xiaoya; Zhou, Jie2; Huan, Zhiguang; Chang, Jiang |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 106期号:1页码:237 |
| ISSN号 | 1552-4973 |
| 关键词 | tricalcium silicate alginate bone cement anti-washout bioactive |
| DOI | 10.1002/jbm.b.33848 |
| 英文摘要 | Previous studies have shown that tricalcium silicate bone cements possess good bioactivity and appropriate degradation rate. However, they also showed some weaknesses such as poor washout resistance, formability and injectability, which have seriously hindered their clinical applications. The purpose of this study was to develop a new type of bone cementstricalcium silicate/sodium alginate (C3S/SA) composites by utilizing the interaction of Ca ions with SA molecules, in which an interpenetrating double-network of calcium hydrate silicate (CSH) and alginate hydrogel was formed to enhance the washout resistance, formability, injectability and compressive strength of C3S. The results confirmed that the washout resistance, formability and injectability of C3S could indeed be greatly enhanced by the introduction of SA. In addition, the compressive strength of the C3S/SA composite cement with an optimum composition could reach 54 MPa, which was significantly higher than that of C3S (i.e., 35.3 MPa). Moreover, the C3S/SA composite cements retained the bioactivity of C3S, such as the activity to induce apatite formation in simulated body fluid and to promote cell proliferation. All these results indicate that the C3S/SA composite cements hold great promise as a new type of bone repair materials for further in vitro and in vivo studies. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 237-244, 2018. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| 出版者 | WILEY |
| WOS记录号 | WOS:000417576500025 |
| 资助机构 | Contract grant sponsor: Natural Science Foundation of China ; contract grant numbers: 81190132, 81401529 ; Contract grant sponsor: Shanghai Pujiang Program ; contract grant number: 14PJ1409400 ; Contract grant sponsor: Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Structure (Shanghai Institute of Ceramics, Chinese Academy of Science) ; contract grant number: SKL201411SIC ; Contract grant sponsor: Natural Science Foundation of China ; contract grant numbers: 81190132, 81401529 ; Contract grant sponsor: Shanghai Pujiang Program ; contract grant number: 14PJ1409400 ; Contract grant sponsor: Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Structure (Shanghai Institute of Ceramics, Chinese Academy of Science) ; contract grant number: SKL201411SIC |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24607]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Delft Univ Technol, Dept Biomech Engn, Mekelweg 2, NL-2628 CD Delft, Netherlands |
| 推荐引用方式 GB/T 7714 | Xu, Chen,Wang, Xiaoya,Zhou, Jie,et al. Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2018,106(1):237, 244. |
| APA | Xu, Chen,Wang, Xiaoya,Zhou, Jie,Huan, Zhiguang,&Chang, Jiang.(2018).Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,106(1),237. |
| MLA | Xu, Chen,et al."Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 106.1(2018):237. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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