Outside-in synthesis of mesoporous silica/molybdenum disulfide nanoparticles for antitumor application
文献类型：期刊论文
| 作者 | Zhao, Jiulong1; Xie, Pei1; Ye, Changqing; Wu, Chenyao; Han, Wencheng; Huang, Mingxian; Wang, Shige; Chen, Hangrong2 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2018 |
| 卷号 | 351页码:157 |
| 关键词 | Outside-in synthesis Silica Molybdenum disulfide Photothermal Tumor |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2018.06.101 |
| 英文摘要 | Very different from traditional inside-out method, which used guest material as the inside core and then surfacecoated outer layer, herein, we propose a facile and unique outside-in approach for the synthesis of high dispersive mesoporous silica nanoparticle (MSN)/MoS2-PEG nanoparticles (SMPs) based on the differences of precursor solubility in different solvents, for the first time. The prepared SMPs exhibit both higher drug loading efficiency of 64.7% owing to the pore structure of mesoporous silica, and excellent photothermal performance with photothermal efficiency of 41.5% due to the inside decorated MoS2 nanosheets, which could be used for the combination of tumor hyperthermia and chemotherapy. The in vivo results indicate that SMPs show great synergistic effect, i.e., the heat produced during PTT can increase the chemotherapy sensitivity of DOX and synergistically improve its therapeutic effect. Such a facile strategy provides a new facile way to construct a novel theranostic agent by integrating different functions into one dosage, and shows a promising approach for the construction of nanomaterials using MSN as a template. |
| 学科主题 | Engineering, Environmental ; Engineering, Chemical |
| WOS记录号 | WOS:000444000000017 |
| 出版者 | ELSEVIER SCIENCE SA |
| 资助机构 | This work was supported by China National Natural Science Foundation of China (Grant Nos. 51702214 ; 51772316), by the National Key Research and Development Program of China (Grant No. 2017YFB0702602), Shanghai Sailing Program (17YF1412600) supported by the Shanghai Committee of Science and Technology, and Chenguang Program supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission (15CG52). Dr. Pei Xie thanks the support from Shanghai Charity Cancer Research Center annual issue in 2017. ; This work was supported by China National Natural Science Foundation of China (Grant Nos. 51702214 ; 51772316), by the National Key Research and Development Program of China (Grant No. 2017YFB0702602), Shanghai Sailing Program (17YF1412600) supported by the Shanghai Committee of Science and Technology, and Chenguang Program supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission (15CG52). Dr. Pei Xie thanks the support from Shanghai Charity Cancer Research Center annual issue in 2017. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24632]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Univ Shanghai Sci & Technol, Coll Sci, 334 Jungong Rd, Shanghai 200093, Peoples R China 2.Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China 3.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, 1295 Dingxi Rd, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jiulong,Xie, Pei,Ye, Changqing,et al. Outside-in synthesis of mesoporous silica/molybdenum disulfide nanoparticles for antitumor application[J]. CHEMICAL ENGINEERING JOURNAL,2018,351:157, 168. |
| APA | Zhao, Jiulong.,Xie, Pei.,Ye, Changqing.,Wu, Chenyao.,Han, Wencheng.,...&Chen, Hangrong.(2018).Outside-in synthesis of mesoporous silica/molybdenum disulfide nanoparticles for antitumor application.CHEMICAL ENGINEERING JOURNAL,351,157. |
| MLA | Zhao, Jiulong,et al."Outside-in synthesis of mesoporous silica/molybdenum disulfide nanoparticles for antitumor application".CHEMICAL ENGINEERING JOURNAL 351(2018):157. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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