Scintillator-Based Nanohybrids with Sacrificial Electron Prodrug for Enhanced X-ray-Induced Photodynamic Therapy
文献类型：期刊论文
| 作者 | Wang, Han2; Lv, Bin3; Tang, Zhongmin2; Zhang, Meng2; Ge, Weiqian3; Liu, Yanyan1; He, Xinhong4; Zhao, Kuaile4; Zheng, Xiangpeng3; He, Mingyuan1 |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 18期号:9页码:5768 |
| 关键词 | Cancer photodynamic therapy photosensitizer sacrificial electron acceptor reactive oxygen species |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.8b02409 |
| 英文摘要 | X-ray-induced photodynamic therapy (X-PDT) has high depth of penetration and has considerable potential for applications in cancer therapy. Scintillators and heavy metals have been adopted to absorb X-rays and transmit the energy to photosensitizers. However, the low efficiency of converting X-rays to reactive oxygen species (ROS) presents a challenge for the use of X-PDT to cure cancer. In this study, a new method based on LiLuF4:Ce@SiO2Ag3PO4@Pt(IV) nanoparticles (LAPNP) is presented that could be used to enhance the curative effects of X-PDT. To make full use of the fluorescence produced by nanoscintillators (LiLuF4:Ce), a cisplatin prodrug Pt(IV) was utilized as a sacrificial electron acceptor to increase the yield of hydroxyl radicals (OH) by increasing the separation of electrons and holes in photosensitizers (Ag3PO4). Additionally, cisplatin is produced upon the acceptance of electrons by Pt(IV) and further enhances the damage caused by (OH)-O-center dot. Via two-step amplification, the potential of LAPNP to enhance the effects of X-PDT has been demonstrated. |
| 学科主题 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| WOS记录号 | WOS:000444793500059 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | This work was financially supported by the National Funds for Distinguished Young Scientists (grant no. 51725202) and the National Natural Science Foundation of China (grant nos. 81472794 and 51702211), the Shanghai Excellent Academic Leaders Program (grant no. 16XD1404000), and the Fundamental Research Funds for the Central Universities. Thanks go to Prof. Shiming Huang and Dr. Mingjie Liu from the School of Physics Science and Engineering, Tongji University, for the assistance with X-ray induced fluorescence spectrum. Thanks go to Prof. Bingwen Hu, Dr. Xiaobing Lou, and Dr. Ming Shen from the Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Materials Science, East China Normal University, for assistance with the 195Pt NMR. ; This work was financially supported by the National Funds for Distinguished Young Scientists (grant no. 51725202) and the National Natural Science Foundation of China (grant nos. 81472794 and 51702211), the Shanghai Excellent Academic Leaders Program (grant no. 16XD1404000), and the Fundamental Research Funds for the Central Universities. Thanks go to Prof. Shiming Huang and Dr. Mingjie Liu from the School of Physics Science and Engineering, Tongji University, for the assistance with X-ray induced fluorescence spectrum. Thanks go to Prof. Bingwen Hu, Dr. Xiaobing Lou, and Dr. Ming Shen from the Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Materials Science, East China Normal University, for assistance with the 195Pt NMR. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24685]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fudan Univ, Shanghai Huadong Hosp, Dept Radiat Oncol, Shanghai 200040, Peoples R China 5.Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Han,Lv, Bin,Tang, Zhongmin,et al. Scintillator-Based Nanohybrids with Sacrificial Electron Prodrug for Enhanced X-ray-Induced Photodynamic Therapy[J]. NANO LETTERS,2018,18(9):5768, 5774. |
| APA | Wang, Han.,Lv, Bin.,Tang, Zhongmin.,Zhang, Meng.,Ge, Weiqian.,...&Bu, Wenbo.(2018).Scintillator-Based Nanohybrids with Sacrificial Electron Prodrug for Enhanced X-ray-Induced Photodynamic Therapy.NANO LETTERS,18(9),5768. |
| MLA | Wang, Han,et al."Scintillator-Based Nanohybrids with Sacrificial Electron Prodrug for Enhanced X-ray-Induced Photodynamic Therapy".NANO LETTERS 18.9(2018):5768. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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