A Bioenvironment-Responsive Versatile Nanoplatform Enabling Rapid Clearance and Effective Tumor Homing for Oxygen-Enhanced Radiotherapy
文献类型：期刊论文
| 作者 | Zhang, Qiuhong1; Chen, Jingwen2; Ma, Ming; Wang, Han2,3; Chen, Hangrong |
| 刊名 | CHEMISTRY OF MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:15页码:5412 |
| ISSN号 | 0897-4756 |
| DOI | 10.1021/acs.chemmater.8b02251 |
| 英文摘要 | Nanoradiosensitizer-augmented cancer radiotherapy (RT) has been widely investigated, whereas the desirable nanoradiosensitizer with the characteristics of rapid clearance, effective tumor homing, and tumor hypoxia relief is still lacking. Herein, bismuth sulfidealbumin composite nanospheres followed by catalase conjugation (denoted as BSNSs-CAT) have been well constructed as a bioenvironment-responsive nanoradiosensitizer platform. The BSNSs-CAT phagocytosed by normal cells demonstrate architectural disintegration into small ones in response to physiological pH, achieving small size-favored rapid clearance, which largely mitigates the concern of long-term toxicity of BSNSs-CAT in normal tissues. More importantly, benefiting from their large size-favored enhanced permeability and retention effect, BSNSs-CAT accumulate efficiently in tumors and remain architecturally stable in a mildly acidic tumor microenvironment (TME), which strongly favors a response with H2O2 overproduced TME. As a result, the produced intratumor oxygen could overcome tumor hypoxia-associated RT resistance, together with the radiosensitization effect of bismuth, collectively enhancing RT efficacy. This research demonstrates a versatile material solution by fully exploring its bioenvironment-responsive nature, offering a new strategy for nanomedicine design and application. |
| 学科主题 | Chemistry, Physical ; Materials Science, Multidisciplinary |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000442186500061 |
| 资助机构 | This work was supported by the National Natural Science Foundation of China (Grants 51772316, 51402329, and 81671740), the National Key Research and Development Program of China (Grants 2017YFB0702602 and 2016YFC0107108), the Key Projects of International Cooperation and Exchanges of the National Natural Science Foundation of China (81720108023), the Shanghai Academic/Technology Research Leader Program (17XD1424200), and the Gaofeng Clinical Medicine Grant of the Shanghai Municipal Education Commission (20152230). ; This work was supported by the National Natural Science Foundation of China (Grants 51772316, 51402329, and 81671740), the National Key Research and Development Program of China (Grants 2017YFB0702602 and 2016YFC0107108), the Key Projects of International Cooperation and Exchanges of the National Natural Science Foundation of China (81720108023), the Shanghai Academic/Technology Research Leader Program (17XD1424200), and the Gaofeng Clinical Medicine Grant of the Shanghai Municipal Education Commission (20152230). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24731]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Radiol, Sch Med, Shanghai 200080, Peoples R China 4.Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qiuhong,Chen, Jingwen,Ma, Ming,et al. A Bioenvironment-Responsive Versatile Nanoplatform Enabling Rapid Clearance and Effective Tumor Homing for Oxygen-Enhanced Radiotherapy[J]. CHEMISTRY OF MATERIALS,2018,30(15):5412, 5421. |
| APA | Zhang, Qiuhong,Chen, Jingwen,Ma, Ming,Wang, Han,&Chen, Hangrong.(2018).A Bioenvironment-Responsive Versatile Nanoplatform Enabling Rapid Clearance and Effective Tumor Homing for Oxygen-Enhanced Radiotherapy.CHEMISTRY OF MATERIALS,30(15),5412. |
| MLA | Zhang, Qiuhong,et al."A Bioenvironment-Responsive Versatile Nanoplatform Enabling Rapid Clearance and Effective Tumor Homing for Oxygen-Enhanced Radiotherapy".CHEMISTRY OF MATERIALS 30.15(2018):5412. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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