A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics
文献类型：期刊论文
| 作者 | Zong, Luyan1; Wu, Huixia1; Lin, Han2; Chen, Yu2 |
| 刊名 | NANO RESEARCH
 |
| 出版日期 | 2018 |
| 卷号 | 11期号:8页码:4149 |
| 关键词 | titanium carbide MXene polyoxometalate dual-mode imaging photothermal therapy |
| ISSN号 | 1998-0124 |
| DOI | 10.1007/s12274-018-2002-3 |
| 英文摘要 | As a new family of two-dimensional (2D) nanomaterials, MXenes have recently attracted much attention because of high performance in versatile applications including energy storage and electrochemistry, but their specific application to biomedicine has been rarely reported, especially for theranostic nanomedicine, i.e., concurrent diagnostic imaging and therapy. This study shows for the first time surface engineering and functionalization of 2D Ti3C2 MXene nanosheets by the integration of GdW10-based polyoxometalates (POMs). These multifunctional GdW10@Ti3C2 composite nanosheets provide hyperthermal treatment with magnetic resonance (MR) and/or computed tomography (CT) imaging guidance toward tumor cells or xenografts. A tumor was effectively eradicated without further reoccurrence during the observation period. GdW10 nanoclusters that were integrated onto the surface of Ti3C2 nanosheets were demonstrated to serve as a contrast agent for contrast-enhanced CT and MR imaging based on their unique composition, thus showing the potential for diagnostic-imaging guidance and monitoring for tumor hyperthermia nanotherapy. The high in vivo biocompatibility of GdW10@Ti3C2 composite nanosheets was demonstrated to guarantee their subsequent translation into a medical treatment. This study provides a novel strategy for broadening the biomedical applications of MXenes by surface engineering and multifunctionalization, which is expected to promote further exploration of biomedical applications of MXenes in nanotheranostics. |
| 学科主题 | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| WOS记录号 | WOS:000440733100019 |
| 出版者 | TSINGHUA UNIV PRESS |
| 资助机构 | We greatly acknowledge the financial support from the National Key Research and Development Program of China (No. 2016YFA0203700), National Natural Science Foundation of China (No. 51672303), Young Elite Scientist Sponsorship Program by CAST (No. 2015QNRC001), the Environmental Functional Materials Innovation Team of Ministry of Education (No. IRT_16R49) and the International Joint Laboratory on Resource Chemistry (IJLRC). ; We greatly acknowledge the financial support from the National Key Research and Development Program of China (No. 2016YFA0203700), National Natural Science Foundation of China (No. 51672303), Young Elite Scientist Sponsorship Program by CAST (No. 2015QNRC001), the Environmental Functional Materials Innovation Team of Ministry of Education (No. IRT_16R49) and the International Joint Laboratory on Resource Chemistry (IJLRC). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24761]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Minist Educ, Key Lab Resource Chem, Shanghai 200234, Peoples R China 2.Shanghai Normal Univ, Shanghai Municipal Educ Comm Key Lab Mol Imaging, Shanghai 200234, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zong, Luyan,Wu, Huixia,Lin, Han,et al. A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics[J]. NANO RESEARCH,2018,11(8):4149, 4168. |
| APA | Zong, Luyan,Wu, Huixia,Lin, Han,&Chen, Yu.(2018).A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics.NANO RESEARCH,11(8),4149. |
| MLA | Zong, Luyan,et al."A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics".NANO RESEARCH 11.8(2018):4149. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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