A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor
文献类型：期刊论文
| 作者 | Song, Ruixue; Zhang, Meng1; Liu, Yanyan; Cui, Zhaowen1; Zhang, Hua2; Tang, Zhongmin1; Chen, Xiaoyan; Wu, Haihong; Yao, Zhenwei2; He, Mingyuan |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 175页码:123 |
| 关键词 | Hypoxia tumor Nanotheranostics Chemotherapy Magnetic resonance imaging Nanotechnology |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2018.05.018 |
| 英文摘要 | Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for the successful treatment of tumors. In the present study, we designed and synthesized a multifunctional rattle-structured nanotheranostic, with the inner core coated by hollow mesoporous silica for chemical drug Doxorubicin (DOX) storage and hypoxia-sensitive MnO2 enrichment. In various acidic micro-environments caused by hypoxia, MnO2 nanosheets could be degraded into manganese ions (Mn2+), which were chelated by the modified Tetraxetanum (DOTA) ligands for real-time Ti-magnetic resonance imaging (T1-MRI), with on-demand DOX release to realize both normoxia and hypoxiasensitive chemotherapy by overcoming hypoxia. Nanotheranostics integrating hypoxia-driven T1-MRI with synergetic chemotherapy have tremendous potential in the intelligent diagnosis, personalized treatment and excellent prognosis of solid tumors in the future. (C) 2018 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000440264500010 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | This work was financially supported by the China National Funds for Distinguished Young Scientists (Grant No. 51725202), the National Natural Science Foundation of China (Grant No. 51702211, 81671732), the Shanghai Excellent Academic Leaders Program (Grant No. 16XD1404000). ; This work was financially supported by the China National Funds for Distinguished Young Scientists (Grant No. 51725202), the National Natural Science Foundation of China (Grant No. 51702211, 81671732), the Shanghai Excellent Academic Leaders Program (Grant No. 16XD1404000). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24764]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Ruixue,Zhang, Meng,Liu, Yanyan,et al. A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor[J]. BIOMATERIALS,2018,175:123, 133. |
| APA | Song, Ruixue.,Zhang, Meng.,Liu, Yanyan.,Cui, Zhaowen.,Zhang, Hua.,...&Bu, Wenbo.(2018).A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor.BIOMATERIALS,175,123. |
| MLA | Song, Ruixue,et al."A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor".BIOMATERIALS 175(2018):123. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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