Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity
文献类型：期刊论文
| 作者 | Xue, Jianmin1; Feng, Chun1; Xia, Lunguo2; Zhai, Dong; Ma, Bing; Wang, Xiaocheng1; Fang, Bing2; Chang, Jiang; Wu, Chengtie |
| 刊名 | CHEMISTRY OF MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:14页码:4646 |
| ISSN号 | 0897-4756 |
| DOI | 10.1021/acs.chemmater.8b01272 |
| 英文摘要 | The creation of a bone substitute with both excellent mechanical strength and bioactivity is still a challenge in bone tissue engineering biomaterials. To this end, inspired by the microstructure of nacre, multilayered graphene oxide/chitosan/calcium silicate (GO/CTS/CS) biomaterials were successfully prepared via a bottom-up assembly approach. The GO/CTS/CS biomaterials emulated the "brick and mortar" layered microstructure via chemical assembly and the multilayered helical cylinder macrostructure. In addition, benefiting from the interface interactions in the layered microstructure as well as the multilayered helical ,cylinder macrostructure, the GO/CTS/CS biomaterials possessed high flexural strength (137.2 MPa), compressive strength (80.2 MPa), toughness (1.46 MJ/m(3)), and specific strength (124.7 MPa MC(-1)m(-3)), which are close to those of cortical bone. Furthermore, because of the bioactive chemical components of GO and CS, the multilayered GO/CTS/CS biomaterials significantly improved osteogenesis and angiogenesis in vitro. Moreover, the multilayered GO/CTS/CS biomaterials showed enhanced in vivo bone-forming ability due to the contributions of bioactive chemical components and the multilayered helical cylinder macrostructure. This work not only provides a biomaterial with excellent mechanical strength and bioactivity but also offers a strategy for fabrication of high-performance biomaterials based on bioinspired chemistry and engineering. |
| 学科主题 | Chemistry, Physical ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000440105500021 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | This work was supported by the National Key Research and Development Program of China (2016YFB0700803), the National Natural Science Foundation of China (51761135103, 31370963, and 81430012), the Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SYS027), and the Science and Technology Commission of Shanghai Municipality (17441903700, 16DZ2260603, and 15XD1503900). ; This work was supported by the National Key Research and Development Program of China (2016YFB0700803), the National Natural Science Foundation of China (51761135103, 31370963, and 81430012), the Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SYS027), and the Science and Technology Commission of Shanghai Municipality (17441903700, 16DZ2260603, and 15XD1503900). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24808]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China 3.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Craniomaxillofacial Sci, Ctr Craniofacial Orthodont,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Jianmin,Feng, Chun,Xia, Lunguo,et al. Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity[J]. CHEMISTRY OF MATERIALS,2018,30(14):4646, 4657. |
| APA | Xue, Jianmin.,Feng, Chun.,Xia, Lunguo.,Zhai, Dong.,Ma, Bing.,...&Wu, Chengtie.(2018).Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity.CHEMISTRY OF MATERIALS,30(14),4646. |
| MLA | Xue, Jianmin,et al."Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity".CHEMISTRY OF MATERIALS 30.14(2018):4646. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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