Porous Nanocomposite Comprising Ultralong Hydroxyapatite Nanowires Decorated with Zinc-Containing Nanoparticles and Chitosan: Synthesis and Application in Bone Defect Repair
文献类型：期刊论文
| 作者 | Sun, Tuan-Wei; Yu, Wei-Lin; Zhu, Ying-Jie; Chen, Feng; Zhang, Yong-Gang; Jiang, Ying-Ying; He, Yao-Hua |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2018 |
| 卷号 | 24期号:35页码:8809 |
| 关键词 | bone regeneration hydroxyapatite nanowires porous scaffold zinc |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201800425 |
| 英文摘要 | Hydroxyapatite nanowires exhibit a great potential in biomedical applications owing to their high specific surface area, high flexibility, excellent mechanical properties, and similarity to mineralized collagen fibrils of natural bone. In this work, zinc-containing nanoparticle-decorated ultralong hydroxyapatite nanowires (Zn-UHANWs) with a hierarchical nanostructure have been synthesized by a one-step solvothermal method. The highly flexible Zn-UHANWs exhibit a hierarchical rough surface and enhanced specific surface area as compared with ultralong hydroxyapatite nanowires (UHANWs). To evaluate the potential application of Zn-UHANWs in bone regeneration, the biomimetic Zn-UHANWs/chitosan (CS) (Zn-UHANWs/CS) composite porous scaffold with 80 wt% Zn-UHANWs was prepared by incorporating Zn-UHANWs into the chitosan matrix by the freeze-drying process. The as-prepared Zn-UHANWs/CS composite porous scaffold exhibits enhanced mechanical properties, highly porous structure, and excellent water retention capacity. In addition, the Zn-UHANWs/CS porous scaffold has a good biodegradability with the sustainable release of Zn, Ca, and P elements in aqueous solution. More importantly, the Zn-UHANWs/CS porous scaffold can promote the osteogenic differentiation of rat bone marrow derived mesenchymal stem cells and facilitate in vivo bone regeneration as compared with the pure CS porous scaffold or UHANWs/CS porous scaffold. Thus, both the Zn-UHANWs and Zn-UHANWs/CS porous scaffold developed in this work are promising for application in bone defect repair. |
| 学科主题 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000435932300019 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | Financial support from the Science and Technology Commission of Shanghai Municipality (15JC1491001) and the National Natural Science Foundation of China (51472259, 81572106) is gratefully acknowledged. ; Financial support from the Science and Technology Commission of Shanghai Municipality (15JC1491001) and the National Natural Science Foundation of China (51472259, 81572106) is gratefully acknowledged. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24859]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.[Sun, Tuan-Wei 2.Zhu, Ying-Jie 3.Chen, Feng 4.Zhang, Yong-Gang 5.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 6.[Sun, Tuan-Wei 7.Zhu, Ying-Jie 8.Zhang, Yong-Gang 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.[Yu, Wei-Lin |
| 推荐引用方式 GB/T 7714 | Sun, Tuan-Wei,Yu, Wei-Lin,Zhu, Ying-Jie,et al. Porous Nanocomposite Comprising Ultralong Hydroxyapatite Nanowires Decorated with Zinc-Containing Nanoparticles and Chitosan: Synthesis and Application in Bone Defect Repair[J]. CHEMISTRY-A EUROPEAN JOURNAL,2018,24(35):8809, 8821. |
| APA | Sun, Tuan-Wei.,Yu, Wei-Lin.,Zhu, Ying-Jie.,Chen, Feng.,Zhang, Yong-Gang.,...&He, Yao-Hua.(2018).Porous Nanocomposite Comprising Ultralong Hydroxyapatite Nanowires Decorated with Zinc-Containing Nanoparticles and Chitosan: Synthesis and Application in Bone Defect Repair.CHEMISTRY-A EUROPEAN JOURNAL,24(35),8809. |
| MLA | Sun, Tuan-Wei,et al."Porous Nanocomposite Comprising Ultralong Hydroxyapatite Nanowires Decorated with Zinc-Containing Nanoparticles and Chitosan: Synthesis and Application in Bone Defect Repair".CHEMISTRY-A EUROPEAN JOURNAL 24.35(2018):8809. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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