Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma
文献类型：期刊论文
| 作者 | Li, Zhenli; Zhang, Han; Han, Jun; Chen, Yu1; Lin, Han1; Yang, Tian |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:25 |
| ISSN号 | 0935-9648 |
| 关键词 | chemotherapy hepatocellular carcinoma mesoporous silica MXene nanomedicine photothermal therapy |
| DOI | 10.1002/adma.201706981 |
| 英文摘要 | Hepatocellular carcinoma (HCC) is one of the most common and deadly gastrointestinal malignancies. Given its insensitivity to traditional systematic chemotherapy, new therapeutic strategies for efficient HCCs treatment are urgently needed. Here, the development of a novel 2D MXene-based composite nanoplatform for highly efficient and synergistic chemotherapy and photothermal hyperthermia against HCC is reported. A surface-nanopore engineering strategy is developed for the MXenes' surface functionalization, which achieves the uniform coating of a thin mesoporous-silica layer onto the surface of 2D Ti3C2 MXene (Ti3C2@mMSNs). This strategy endows MXenes with well-defined mesopores for on-demand drug release/delivery, enhanced hydrophilicity/dispersity, and abundant surface chemistry for targeting engineering. Systematic in vitro and in vivo evaluations have demonstrated the high active-targeting capability of arginine-glycine-aspartic acid (RGD)-targeting Ti3C2@mMSNs into tumor, and the synergistic chemotherapy (contributed by the mesoporous shell) and photothermal hyperthermia (contributed by the Ti3C2 MXene core) completely eradicate the tumor without obvious reoccurrence. This work not only provides a novel strategy for efficiently combating HCC by developing MXene-based composite nanoplatforms, but also paves a new way for extending the biomedical applications of MXenes by surface-nanopore engineering. |
| 学科主题 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000435258600007 |
| 资助机构 | Z.L. and H.Z. contributed equally to this work. The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant No. 51722211, 51672303, 81472284, 81672699), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. ; Z.L. and H.Z. contributed equally to this work. The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant No. 51722211, 51672303, 81472284, 81672699), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24863]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, Shanghai 200438, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhenli,Zhang, Han,Han, Jun,et al. Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma[J]. ADVANCED MATERIALS,2018,30(25). |
| APA | Li, Zhenli,Zhang, Han,Han, Jun,Chen, Yu,Lin, Han,&Yang, Tian.(2018).Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma.ADVANCED MATERIALS,30(25). |
| MLA | Li, Zhenli,et al."Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma".ADVANCED MATERIALS 30.25(2018). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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