2D magnetic titanium carbide MXene for cancer theranostics
文献类型：期刊论文
| 作者 | Liu, Zhuang; Zhao, Menglong1,2; Lin, Han3; Dai, Chen4; Ren, Caiyue; Zhang, Shengjian; Peng, Weijun; Chen, Yu3 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:21页码:3541 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c8tb00754c |
| 英文摘要 | Fast progress of two-dimensional (2D) materials has catalyzed the emergence of diverse new 2D nanosystems for versatile applications, among which 2D MXenes have attracted broad interest but their single functionality significantly restricts their extensive applications, especially in nanomedicine. Herein we report, for the first time, on the construction of superparamagnetic 2D Ti3C2 MXenes for highly efficient cancer theranostics, which is based on the surface chemistry of specific MXenes for the in situ growth of superparamagnetic Fe3O4 nanocrystals onto the surface of Ti3C2 MXenes. These magnetic Ti3C2-IONPs MXene composites exhibit a high T-2 relaxivity of 394.2 mM(-1) s(-1) and efficient contrast-enhanced magnetic resonance imaging of tumors, providing the potential for therapeutic guidance. Importantly, these superparamagnetic MXenes have shown high photothermal conversion efficiency (48.6%) to guarantee the efficient photothermal killing of cancer cells and ablation of tumor tissues, which has been systematically demonstrated both in vitro and in vivo. The high biocompatibility of these elaborately designed magnetic Ti3C2-based MXene composites guarantees their further potential clinical translation. This report paves a new way for the functionalization of MXene-based 2D nanosheets for broadening their novel applications based on the unique surface chemistry of MXenes, especially in theranostic nanomedicine. |
| 学科主题 | Materials Science, bioMaterials |
| WOS记录号 | WOS:000434242500012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), the National Natural Science Foundation of China (Grant No. 51722211 and 51672303), the Natural Science Foundation of Shanghai (Grant No. 15ZR1407700) and the Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). ; We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), the National Natural Science Foundation of China (Grant No. 51722211 and 51672303), the Natural Science Foundation of Shanghai (Grant No. 15ZR1407700) and the Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24871]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Dept Oncol,Dept Radiol, Shanghai 200032, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Shanghai Med Coll, Dept Radiol, Shanghai 200032, Peoples R China 3.Shanghai Inst Med Imaging, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 5.Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Ultrasound Med, Shanghai 200072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhuang,Zhao, Menglong,Lin, Han,et al. 2D magnetic titanium carbide MXene for cancer theranostics[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(21):3541, 3548. |
| APA | Liu, Zhuang.,Zhao, Menglong.,Lin, Han.,Dai, Chen.,Ren, Caiyue.,...&Chen, Yu.(2018).2D magnetic titanium carbide MXene for cancer theranostics.JOURNAL OF MATERIALS CHEMISTRY B,6(21),3541. |
| MLA | Liu, Zhuang,et al."2D magnetic titanium carbide MXene for cancer theranostics".JOURNAL OF MATERIALS CHEMISTRY B 6.21(2018):3541. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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