Achieving stem cell imaging and osteogenic differentiation by using nitrogen doped graphene quantum dots
文献类型：期刊论文
| 作者 | Geng, Hao1; Qiu, Jiajun1; Zhu, Hongqin; Liu, Xuanyong |
| 刊名 | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
 |
| 出版日期 | 2018 |
| 卷号 | 29期号:6 |
| ISSN号 | 0957-4530 |
| DOI | 10.1007/s10856-018-6095-8 |
| 英文摘要 | Nitrogen doped graphene quantum dots (N-GQDs) were synthesized to explore and extend their potential applications in biomedical field. The hemocompatibility and cytotoxity of the obtained N-GQDs were primarily assessed at concentrations ranging from 10 to 100 mu g/ml. From the results, it was found that the proliferation of rat Bone Mesenchymal Stem Cells (rBMSCs) was depressed to a certain extent after incubating with the high concentration (100 mu g/ml) of N-GQDs. The nanoscale size and superior dispersibility endow N-GQDs with good cell permeability. Meanwhile, owing to their intrinsic photoluminescence characteristic, the N-GQDs can be used to label cells with high uniformity and light stability in absence of chemical dyes. More importantly, the up-regulated expression of alkaline phosphate (ALP), extracellular matrix, osteopontin (OPN) and osteocalcin (OCN) in rBMSCs cultured with N-GQDs, indicating N-GQDs have the abilities to promote rBMSCs osteogenic differentiation. This work would help give a new insight into the advantages of N-GQDs and pave the way for application of N-GQDs in regenerative medicine fields. [GRAPHICS] . |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000435079000003 |
| 出版者 | SPRINGER |
| 资助机构 | This work was supported by the National Science Foundation for Distinguished Young Scholars of China (51525207), National Natural Science Foundation of China (31570973), Shanghai Committee of Science and Technology, China (15441904900) and International Partnership Program of Chinese Academy of Sciences (GJHZ1850). ; This work was supported by the National Science Foundation for Distinguished Young Scholars of China (51525207), National Natural Science Foundation of China (31570973), Shanghai Committee of Science and Technology, China (15441904900) and International Partnership Program of Chinese Academy of Sciences (GJHZ1850). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24882]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Hao,Qiu, Jiajun,Zhu, Hongqin,et al. Achieving stem cell imaging and osteogenic differentiation by using nitrogen doped graphene quantum dots[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2018,29(6). |
| APA | Geng, Hao,Qiu, Jiajun,Zhu, Hongqin,&Liu, Xuanyong.(2018).Achieving stem cell imaging and osteogenic differentiation by using nitrogen doped graphene quantum dots.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,29(6). |
| MLA | Geng, Hao,et al."Achieving stem cell imaging and osteogenic differentiation by using nitrogen doped graphene quantum dots".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 29.6(2018). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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