Chemical Design of Nuclear-Targeting Mesoporous Silica Nanoparticles for Intra-nuclear Drug Delivery
文献类型：期刊论文
| 作者 | Pan, Limin; Shi, Jianlin |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 36期号:6页码:481 |
| 关键词 | nuclear targeting mesoporous silica nanoparticles drug delivery cancer therapy nanomedicine |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201800032 |
| 英文摘要 | Targeted drug delivery has been widely explored for efficient tumor therapy with desired efficacy but minimized side effects. It is widely known that large numbers of DNA-toxins, such as doxorubicin, genes, reactive oxygen species, serving as therapeutic agents, can result in maximized therapeutic effects via the interaction directly with DNA helix. So after cellular uptake, these agents should be further delivered into cell nuclei to play their essential roles in damaging the DNA helix in cancer cells. Here, we demonstrate the first paradigm established in our laboratory in developing nuclear-targeted drug delivery systems (DDSs) based on MSNs for enhanced therapeutic efficiency in the hope of speeding their translation into the clinics. Firstly, nuclear-targeting DDSs based on MSNs, capable of intranuclear accumulation and drug release therein, were designed and constructed for the first time, resulting in much enhanced anticancer effects both in vitro and in vivo. Such an MSNs-based and nuclear-targeted drug/agent delivery strategy was further applied to overcome multidrug resistance (MDR) of malignant tumors, intra-nuclearly deliver therapeutic genes, photosensitizers, radio-enhancement agents and photothermal agents to realize efficient gene therapy, photodynamic therapy, radiation therapy and photothermal therapy, respectively. |
| 学科主题 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000431977300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | This work was financially supported by National Natural Science Foundation of China (Grant No. 51402338) and Youth Innovation Promotion Association CAS (Grant No. 2017299). ; This work was financially supported by National Natural Science Foundation of China (Grant No. 51402338) and Youth Innovation Promotion Association CAS (Grant No. 2017299). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24896]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Limin,Shi, Jianlin. Chemical Design of Nuclear-Targeting Mesoporous Silica Nanoparticles for Intra-nuclear Drug Delivery[J]. CHINESE JOURNAL OF CHEMISTRY,2018,36(6):481, 486. |
| APA | Pan, Limin,&Shi, Jianlin.(2018).Chemical Design of Nuclear-Targeting Mesoporous Silica Nanoparticles for Intra-nuclear Drug Delivery.CHINESE JOURNAL OF CHEMISTRY,36(6),481. |
| MLA | Pan, Limin,et al."Chemical Design of Nuclear-Targeting Mesoporous Silica Nanoparticles for Intra-nuclear Drug Delivery".CHINESE JOURNAL OF CHEMISTRY 36.6(2018):481. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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