Fabrication of Multiple-Layered Hydrogel Scaffolds with Elaborate Structure and Good Mechanical Properties via 3D Printing and Ionic Reinforcement
文献类型：期刊论文
| 作者 | Wang, Xiaotong1; Wei, Changzheng; Cao, Bin; Jiang, Lixia; Hou, Yongtai1; Chang, Jiang2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:21页码:18338 |
| 关键词 | hydroxybutyl chitosan 3D printing hydrogel specific ion effect tissue engineering |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b04116 |
| 英文摘要 | A major challenge in three-dimensional (3D) printing of hydrogels is the fabrication of stable constructs with high precision and good mechanical properties and biocompatibility. Existing methods typically feature complicated reinforcement steps or use potentially toxic components, such as photocuring polymers and crosslinking reagents. In this study, we used a thermally sensitive hydrogel, hydroxybutyl chitosan (HBC), for 3D-printing applications. For the first time, we demonstrated that this modified polysaccharide is affected by the specific ion effect. As the salt concentration was increased and stronger kosmotropic anions were used, the lower critical solution temperature of the HBC decreased and the storage modulus was improved, indicating a more hydrophobic structure and stronger molecular chain interactions. On the basis of the thermosensitivity and the ion effects of HBC, a 25 layered hydrogel scaffold with strong mechanical properties and an elaborate structure was prepared via a 3D-printing method and one-step ionic post-treatment. In particular, the scaffold treated with 10% NaCl solution exhibited a tunable elastic modulus of 73.2 kPa to 40 MPa and excellent elastic recovery, as well as biodegradability and cytocompatibility, suggesting the potential for its applications to cartilage tissue repair. By simply controlling the temperature and salt concentrations, this novel approach provides a convenient and green route to improving the structural accuracy and regulating the properties of 3D-printed hydrogel constructs. |
| 学科主题 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000434101200086 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | This work was supported by Science and Technology Commission of Shanghai Municipality (16441907000). ; This work was supported by Science and Technology Commission of Shanghai Municipality (16441907000). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24905]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Shanghai Qisheng Biol Preparat Co Ltd, Shanghai 201106, Peoples R China 2.Shanghai Haohai Biol Technol Co Ltd, Shanghai 200052, Peoples R China 3.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaotong,Wei, Changzheng,Cao, Bin,et al. Fabrication of Multiple-Layered Hydrogel Scaffolds with Elaborate Structure and Good Mechanical Properties via 3D Printing and Ionic Reinforcement[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(21):18338, 18350. |
| APA | Wang, Xiaotong,Wei, Changzheng,Cao, Bin,Jiang, Lixia,Hou, Yongtai,&Chang, Jiang.(2018).Fabrication of Multiple-Layered Hydrogel Scaffolds with Elaborate Structure and Good Mechanical Properties via 3D Printing and Ionic Reinforcement.ACS APPLIED MATERIALS & INTERFACES,10(21),18338. |
| MLA | Wang, Xiaotong,et al."Fabrication of Multiple-Layered Hydrogel Scaffolds with Elaborate Structure and Good Mechanical Properties via 3D Printing and Ionic Reinforcement".ACS APPLIED MATERIALS & INTERFACES 10.21(2018):18338. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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