Accelerated host angiogenesis and immune responses by ion release from mesoporous bioactive glass
文献类型：期刊论文
| 作者 | Zhou, Yinghong1,2; Han, Shengwei2,6; Xiao, Lan1,2; Han, Pingping2,4; Wang, Shengfang; He, Jie2,5; Chang, Jiang2,3; Wu, Chengtie2,3; Xiao, Yin1,2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:20页码:3274 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c8tb00683k |
| 英文摘要 | Angiogenesis represents a major focus for novel therapeutic approaches to the treatment and management of multiple pathological conditions, such as ischemic heart disease and critical-sized bone defect. The complex process of angiogenesis begins when cells within a tissue respond to hypoxia by increasing their production of vascular endothelial growth factor (VEGF). Loading biomaterials with angiogenic therapeutics have emerged as a promising approach for developing superior biomaterials for tissue repair and regeneration due to the possibility of reducing treatment costs and side effects when compared to the use of growth factors or genetic engineering approaches. Trace elements, such as copper (Cu), have been reported to be capable of inhibiting prolyl hydroxylases leading to the accumulation and activation of hypoxia-inducible factor-1 (HIF-1), a major transcription factor regulating the expression of VEGF. It has also recently been speculated that the artifically induced hypoxic microenvironment may regulate the local immune response, which in turn, further facilitates the tissue repair process. The present study has incorporated ionic Cu2+ into mesoporous bioactive glass (MBG), a promising bioactive material system for regenerative medicine, and investigated its effect on angiogenesis and immune responses both in vitro and in vivo. Our results demonstrated that hypoxia-mimicking materials could induce VEGF secretion of bone marrow-derived mesenchymal stromal cells (BMSCs), which provided a positive feedback loop for early blood vessel formation by stimulating migration and tube formation of human umbilical vein endothelial cells (HUVECs). Furthermore, a tissue-regenerative macrophage subtype was triggered by Cu-MBG, leading to superior angiogenic responses (tube formation and angiogenic gene expression) compared to the traditional MBG material. It is concluded that the addition of inorganic ions leads to enhanced angiogenesis and immune responses, which holds promise for the development of functional tissue-engineered constructs to repair and regenerate damaged tissues and organs. |
| 学科主题 | Materials Science, bioMaterials |
| WOS记录号 | WOS:000433256100008 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | Funding for this study was provided by the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) Lab Travel Grant (Y. Z.), the National Health and Medical Research Council (NHMRC) Early Career Fellowship (Grant No. 1105035), the National Natural Science Foundation of China (NSFC) Young Scientists Fund (Grant No. 81700969), the National Key Research and Development Program of China (2016YFB0700803), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (QYZDB-SSW-SYS027) and the Program of Shanghai Outstanding Academic Leaders (15XD1503900). ; Funding for this study was provided by the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) Lab Travel Grant (Y. Z.), the National Health and Medical Research Council (NHMRC) Early Career Fellowship (Grant No. 1105035), the National Natural Science Foundation of China (NSFC) Young Scientists Fund (Grant No. 81700969), the National Key Research and Development Program of China (2016YFB0700803), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (QYZDB-SSW-SYS027) and the Program of Shanghai Outstanding Academic Leaders (15XD1503900). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24907]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia 2.Guangzhou Med Univ, Key Lab Oral Med, Guangzhou Inst Oral Dis, Stomatol Hosp, Guangzhou 510140, Guangdong, Peoples R China 3.Queensland Univ Technol, Australia China Ctr Tissue Engn & Regenerat Med A, Brisbane, Qld 4059, Australia 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 5.Univ Queensland, Stem Cell Ageing & Regenerat Engn UQ StemCARE, AIBN, Brisbane, Qld 4072, Australia 6.Wuhan Gen Hosp Peoples Liberat Army, Dept Stomatol, Wuhan 430070, Hubei, Peoples R China 7.Nanjing Univ, Sch Med, Nanjing Stomatol Hosp, Nanjing 210093, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yinghong,Han, Shengwei,Xiao, Lan,et al. Accelerated host angiogenesis and immune responses by ion release from mesoporous bioactive glass[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(20):3274, 3284. |
| APA | Zhou, Yinghong.,Han, Shengwei.,Xiao, Lan.,Han, Pingping.,Wang, Shengfang.,...&Xiao, Yin.(2018).Accelerated host angiogenesis and immune responses by ion release from mesoporous bioactive glass.JOURNAL OF MATERIALS CHEMISTRY B,6(20),3274. |
| MLA | Zhou, Yinghong,et al."Accelerated host angiogenesis and immune responses by ion release from mesoporous bioactive glass".JOURNAL OF MATERIALS CHEMISTRY B 6.20(2018):3274. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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