In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy
文献类型：期刊论文
| 作者 | Tang, Hailin; Guo, Yuan1,2; Peng, Li; Fang, Hui; Wang, Zhigang1,2; Zheng, Yuanyi4; Ran, Haitao1,2; Chen, Yu3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:18页码:15428 |
| ISSN号 | 1944-8244 |
| 关键词 | HIFU chemotherapy PLGA nanomedicine synergistic therapy cancer |
| DOI | 10.1021/acsami.8b01967 |
| 英文摘要 | As one of the most representative noninvasive therapeutic modalities, high-intensity focused ultrasound (HIFU) has shown great promise for cancer therapy, but its low therapeutic efficacy and biosafety significantly hinder further extensive clinical translation and application. In this work, we report on the construction of a multifunctional theranostic nanoplatform to synergistically enhance the HIFU-therapeutic efficacy based on nanomedicine. A targeted and temperature-responsive theranostic nanoplatform (PFH/DOX@PLGA/Fe3O4-FA) has been designed and fabricated for efficient ultrasound/magnetic resonance dual-modality imaging-guided HIFU/chemo synergistic therapy. Especially, the folate was conjugated onto the surface of the nanoplatform for achieving active targeting to hepatoma cells by receptor ligand interaction, which facilitates accumulation of the nanoplatforms into the tumor site. The integrated superparamagnetic iron oxide nanoparticles could generate the contrast enhancement in T-2-weighted magnetic resonance imaging. By virtue of the thermal effect as generated by HIFU, liquid gas phase transition of perfluorohexane (PFH) in nanocomposites was induced to generate PFH microbubbles, which achieved the contrast-enhanced ultrasound imaging and significantly improved the HIFU ablation efficacy. The loaded anticancer drugs could be released from the nanocomposites in a controllable manner (both pH and HIFU responsiveness). These multifunctional nanocomposites have been demonstrated to efficiently suppress the tumor growth based on the enhanced and synergistic chemotherapy and HIFU ablation, providing an efficient theranostic nanoplatform for cancer treatment. |
| 学科主题 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000432205800013 |
| 资助机构 | We greatly acknowledge the financial support from the National Key R&D Program of China (grant no. 2016YFA0203700), the Science and Technology Project of Zhejiang Province (grant no. 2015C33189), the Health Department of Zhejiang Province (grant no. 2007A119), the National Nature Science Foundation of China (grant nos. 51722211, 81630047 and 51672303), and Young Elite Scientist Sponsorship Program by CAST (grant no. 2015QNRC001). ; We greatly acknowledge the financial support from the National Key R&D Program of China (grant no. 2016YFA0203700), the Science and Technology Project of Zhejiang Province (grant no. 2015C33189), the Health Department of Zhejiang Province (grant no. 2007A119), the National Nature Science Foundation of China (grant nos. 51722211, 81630047 and 51672303), and Young Elite Scientist Sponsorship Program by CAST (grant no. 2015QNRC001). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24924]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Tongde Hosp Zhejiang Prov, Dept Ultrasound, Hangzhou 310012, Zhejiang, Peoples R China 2.Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China 3.Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 5.Shanghai Jiao Tong Univ, Affiliated Shanghai Peoples Hosp 6, Shanghai Inst Ultrasound Med, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Hailin,Guo, Yuan,Peng, Li,et al. In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(18):15428, 15441. |
| APA | Tang, Hailin.,Guo, Yuan.,Peng, Li.,Fang, Hui.,Wang, Zhigang.,...&Chen, Yu.(2018).In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy.ACS APPLIED MATERIALS & INTERFACES,10(18),15428. |
| MLA | Tang, Hailin,et al."In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy".ACS APPLIED MATERIALS & INTERFACES 10.18(2018):15428. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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