Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow
文献类型：期刊论文
| 作者 | Han, Xiaoxia; Huang, Ju; Jing, Xiangxiang1; Yang, Dayan1; Lin, Han2; Wang, Zhigang; Li, Pan; Chen, Yu2 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2018 |
| 卷号 | 12期号:5页码:4545 |
| 关键词 | black titania sonodynamic therapy photothermal therapy nanomedicine cancer |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b00899 |
| 英文摘要 | The conventional inorganic semiconductors are not suitable for in vivo therapeutic nanomedicine because of the lack of an adequate and safe irradiation source to activate them. This work reports on the rational design of titania (TiO2)-based semiconductors for enhanced and synergistic sono-/photoinduced tumor eradication by creating an oxygen-deficient TiO2-x layer onto the surface of TiO2 nanocrystals, which can create a crystalline -disordered core/shell structure (TiO2@ TiO2-x) with black color. As found in the lessons from traditional photocatalysis, such an oxygen-deficient TiO2-x layer with abundant oxygen defects facilitates and enhances the separation of electrons (e(-)) and holes (h(+)) from the energy-band structure upon external ultrasound irradiation, which can significantly improve the efficacy of sono-triggered sonocatalytic tumor therapy. Such an oxygen-deficient TiO2-x layer can also endow black titania nanoparticles with high photothermal-conversion efficiency (39.8%) at the NIR-II biowindow (1064 nm) for enhanced photothermal hyperthermia. Both in vitro cell level and systematic in vivo tumor-bearing mice xenograft evaluations have demonstrated the high synergistic efficacy of combined and enhanced sonodynamic therapy and photothermal ablation as assisted by oxygen-deficient black titania, which has achieved complete tumor eradication with high therapeutic biosafety and without obvious reoccurrence. This work not only provides the paradigm of high therapeutic efficacy of a combined sono-/photoinduced tumor-treatment protocol but also significantly broadens the nanomedical applications of semiconductor-based nanoplatforms by rational design of their nanostructures and control of their physiochemical properties. |
| 学科主题 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000433404500051 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | We greatly acknowledge financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Natural Science Foundation of China (Grant No. 51722211, 51672303, 81760317, 31630026, and 81771847), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). We thank Dr. Tianquan Lin from SICCAS for providing assistance in the fabrication of black TiO |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24941]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chongqing Med Univ, Affiliated Hosp 2, Ultrasound Dept, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 2.Hainan Gen Hosp, Dept Ultrasound, Haikou 570311, Hainan, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Xiaoxia,Huang, Ju,Jing, Xiangxiang,et al. Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow[J]. ACS NANO,2018,12(5):4545, 4555. |
| APA | Han, Xiaoxia.,Huang, Ju.,Jing, Xiangxiang.,Yang, Dayan.,Lin, Han.,...&Chen, Yu.(2018).Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow.ACS NANO,12(5),4545. |
| MLA | Han, Xiaoxia,et al."Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow".ACS NANO 12.5(2018):4545. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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