The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration
文献类型：期刊论文
| 作者 | Chen, Zetao1; Chen, Lingling1; Liu, Runheng1; Lin, Yixiong1; Chen, Shoucheng1; Lu, Shifeier2,3; Lin, Zhengmei1; Chen, Zhuofan1; Wu, Chengtie4; Xiao, Yin1,2,3 |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:5页码:1007 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/c7bm00869d |
| 英文摘要 | A barrier membrane is a major component of guided bone regeneration (GBR), which is traditionally viewed as a physical barrier. Due to its "foreign body" nature, the implantation of a barrier membrane would inevitably modulate immune response and subsequently affect bone dynamics, which has long been neglected. To bridge this knowledge gap, we investigated the osteoimmunomodulatory effects of barrier collagen membranes. It is found that barrier collagen membranes elicit significant effects on modulating the osteoimmune response of macrophages, by upregulating the expression of pro-inflammatory cytokines (TNF alpha, IL-1 beta, IL-6, and IL-18) and osteogenic factors (BMP2/6, WNT10b, OSM). The modulated-osteoimmune environment was beneficial for the osteogenic differentiation of BMSCs, due to the activation of BMP, canonical WNT/beta-catenin, and OSM signalling pathways. The membrane-mediated osteoimmunomodulation was further modulated to show whether osteogenesis could be enhanced via manipulating the membrane-mediated osteoimmunomodulation. The membrane-mediated osteoimmune response was successfully tuned through coating the collagen membranes with nanometersized bioactive glass Ca2ZnSi2O7 by pulsed laser deposition, which is indicated from the change in the expression profile of inflammatory cytokines and the upregulated expression of osteogenic factors. The modulated osteoimmune environment enhanced the osteogenic differentiation of BMSCs, suggesting that collagen membranes with nanometer-sized Ca2ZnSi2O7 coating can be promising for GBR applications. These results collectively imply that barrier membranes are bioactive barriers with an osteoimmunomodulatory effect and not just physical barriers. New generation barrier membranes should be designed with a favourable osteoimmunomodulatory property. |
| 学科主题 | Materials Science, bioMaterials |
| WOS记录号 | WOS:000431111600009 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | The authors would like to acknowledge the company Geistlich China for their support in providing BioGide (R) collagen membranes. Funding for this study was provided by the National High Technology Research and Development Program of China (863 Program, SS2015AA020302), the Natural Science Foundation of China (Grant 81701024 and 31370963), the Osteology Foundation (Young Researcher Grant 2015), the Fundamental Research Funds for the Central Universities (17ykpy70), the Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2017), the 100 Top Talents Program of Sun Yat-sen University (Z.C.) and the Recruitment Program of Global Young Talent, China (Z.C.). ; The authors would like to acknowledge the company Geistlich China for their support in providing BioGide (R) collagen membranes. Funding for this study was provided by the National High Technology Research and Development Program of China (863 Program, SS2015AA020302), the Natural Science Foundation of China (Grant 81701024 and 31370963), the Osteology Foundation (Young Researcher Grant 2015), the Fundamental Research Funds for the Central Universities (17ykpy70), the Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2017), the 100 Top Talents Program of Sun Yat-sen University (Z.C.) and the Recruitment Program of Global Young Talent, China (Z.C.). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24945]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Guangzhou 510055, Guangdong, Peoples R China 2.Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Guangdong, Peoples R China 3.Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia 4.Queensland Univ Technol, Australia China Ctr Tissue Engn & Regenerat Med, Brisbane, Qld 4059, Australia 5.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zetao,Chen, Lingling,Liu, Runheng,et al. The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration[J]. BIOMATERIALS SCIENCE,2018,6(5):1007, 1019. |
| APA | Chen, Zetao.,Chen, Lingling.,Liu, Runheng.,Lin, Yixiong.,Chen, Shoucheng.,...&Xiao, Yin.(2018).The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration.BIOMATERIALS SCIENCE,6(5),1007. |
| MLA | Chen, Zetao,et al."The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration".BIOMATERIALS SCIENCE 6.5(2018):1007. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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