Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy
文献类型：期刊论文
| 作者 | Wang, Liying1,2; Huo, Minfeng2; Chen, Yu; Shi, Jianlin |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 163页码:1 |
| ISSN号 | 0142-9612 |
| 关键词 | Framework engineering Catalytic nanomedicine Fenton-like reaction Tumor microenvironment Coordination degradation |
| DOI | 10.1016/j.biomaterials.2018.02.018 |
| 英文摘要 | Inorganic mesoporous silica-based nanovehicles are highly promising for drug delivery but still suffer from the disadvantages of lacking functionality and poor biodegradability on account of the inert silica framework. Moreover, conventional cancer therapeutics typically employ toxic anticancer drugs or invasive external irradiations, which will inevitably give rise to severe adverse effects and diminished therapeutic outcome. In this work, we report on the iron engineered framework of mesoporous silica nanoparticles (MSNs) to fabricate a nanocatalyst with biodegradable and catalytic framework via a "dissolution-regeneration" strategy (designated as rFeO(x)-HMSN). Based on the abundant overexpressed hydrogen peroxide (H2O2) and mild acidic nature in tumor microenvironment (TME), rFeO(x)-HMSN nanocatalyst could trigger in-situ Fenton-like reactions to produce highly toxic hydroxyl radicals (center dot OH), causing remarkable oxidative damages against tumor cells/xenografts. Additionally, the iron-engineered rFeO(x)-HMSN nanocatalyst could readily collapse via an iron-extraction strategy under protein-rich environment, thereby improving the biodegradability of rFeO(x)-HMSN nanocatalyst. This work paves a promising way to engineer the inert framework of MSN into functional, biodegradable and catalytic nanoplatform, featuring effective tumor-therapeutic outcome and stimuli-responsive biodegradation concurrently. (C) 2018 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000428606700001 |
| 资助机构 | We greatly acknowledge the financial support from National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant No. 51722211, 51672303), Young Elite Scientist Sponsorship Program by CAST, China (Grant No. 2015QNRC001), Natural Science Foundation of Shanghai, China (Grant No. 13ZR1463500), and Youth Innovation Promotion Association, China (Grant No. 2013169). ; We greatly acknowledge the financial support from National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant No. 51722211, 51672303), Young Elite Scientist Sponsorship Program by CAST, China (Grant No. 2015QNRC001), Natural Science Foundation of Shanghai, China (Grant No. 13ZR1463500), and Youth Innovation Promotion Association, China (Grant No. 2013169). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24956]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Liying,Huo, Minfeng,Chen, Yu,et al. Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy[J]. BIOMATERIALS,2018,163:1, 13. |
| APA | Wang, Liying,Huo, Minfeng,Chen, Yu,&Shi, Jianlin.(2018).Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy.BIOMATERIALS,163,1. |
| MLA | Wang, Liying,et al."Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy".BIOMATERIALS 163(2018):1. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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