Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells
文献类型：期刊论文
| 作者 | Ding, Ding1; Xie, Youtao; Li, Kai; Huang, Liping; Zheng, Xuebin |
| 刊名 | MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 11期号:4 |
| 关键词 | micro/nano structure tantalum coating osteogenic differentiation nanotopographical modification plasma spraying |
| ISSN号 | 1996-1944 |
| DOI | 10.3390/ma11040546 |
| 英文摘要 | Recently, tantalum has been attracting much attention for its anticorrosion resistance and biocompatibility, and it has been widely used in surface modification for implant applications. To improve its osteogenic differentiation of human bone marrow stem cells (hBMSCs), a micro/nano structure has been fabricated on the tantalum coating surface through the combination of anodic oxidation and plasma spraying method. The morphology, composition, and microstructure of the modified coating were comprehensively studied by employing scanning electron microscopy (SEM), X-ray diffraction (XRD) as well as transmission electron microscopy (TEM). The effects of hierarchical structures as well as micro-porous structure of tantalum coating on the behavior for human bone marrow stem cells (hBMSCs) were evaluated and compared at both cellular and molecular levels in vitro. The experimental results show that a hierarchical micro/nano structure with Ta2O5 nanotubes spread onto a micro-scale tantalum coating has been fabricated successfully, which is confirmed to promote cell adhesion and spreading. Besides, the hierarchical micro/nano tantalum coating can provide 1.5 similar to 2.1 times improvement in gene expression, compared with the micro-porous tantalum coating. It demonstrates that it can effectively enhance the proliferation and differentiation of hBMSCs in vitro. |
| 学科主题 | Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000434710200088 |
| 出版者 | MDPI |
| 资助机构 | This work was supported by National Natural Science Foundation of China (Grant No. 51502328) and Shanghai Science and Technology Committee (Grant No. 17441904400). ; This work was supported by National Natural Science Foundation of China (Grant No. 51502328) and Shanghai Science and Technology Committee (Grant No. 17441904400). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25018]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat CAS, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Ding,Xie, Youtao,Li, Kai,et al. Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells[J]. MATERIALS,2018,11(4). |
| APA | Ding, Ding,Xie, Youtao,Li, Kai,Huang, Liping,&Zheng, Xuebin.(2018).Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells.MATERIALS,11(4). |
| MLA | Ding, Ding,et al."Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells".MATERIALS 11.4(2018). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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