Efficient Active Oxygen Free Radical Generated in Tumor Cell by Loading-(HCONH2)center dot H2O2 Delivery Nanosystem with Soft-X-ray Radiotherapy
文献类型：期刊论文
| 作者 | Xu, Lei; Shao, Yiran1; Chang, Chengkang2; Zhu, Yingchun1,3 |
| 刊名 | MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 11期号:4 |
| 关键词 | formamide peroxide ROS soft-X-ray radiotherapy tumor hypoxia |
| ISSN号 | 1996-1944 |
| DOI | 10.3390/ma11040596 |
| 英文摘要 | Tumor hypoxia is known to result in radiotherapy resistance and traditional radiotherapy using super-hard X-ray irradiation can cause considerable damage to normal tissue. Therefore, formamide peroxide (FPO) with high reactive oxygen content was employed to enhance the oxygen concentration in tumor cells and increase the radio-sensitivity of low-energy soft-X-ray. To improve stability of FPO, FPO is encapsulated into polyacrylic acid (PAA)-coated hollow mesoporous silica nanoparticles (FPO@HMSNs-PAA). On account of the pH-responsiveness of PAA, FPO@HMSNs-PAA will release more FPO in simulated acidic tumor microenvironment (pH 6.50) and subcellular endosomes (pH 5.0) than in simulated normal tissue media (pH 7.40). When exposed to soft-X-ray irradiation, the released FPO decomposes into oxygen and the generated oxygen further formed many reactive oxygen species (ROS), leading to significant tumor cell death. The ROS-mediated cytotoxicity of FPO@HMSNs-PAA was confirmed by ROS-induced green fluorescence in tumor cells. The presented FPO delivery system with soft-X-ray irradiation paves a way for developing the next opportunities of radiotherapy toward efficient tumor prognosis. |
| 学科主题 | Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000434710200138 |
| 出版者 | MDPI |
| 资助机构 | This work was supported by the National Natural Science Foundation of China (No. 51572283, No. 51232007) ; the Innovation Fund of SICCAS (No. Y75ZC8180G) ; Shanghai Sailing Program (No. 17YF1421700). ; This work was supported by the National Natural Science Foundation of China (No. 51572283, No. 51232007) ; the Innovation Fund of SICCAS (No. Y75ZC8180G) ; Shanghai Sailing Program (No. 17YF1421700). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25020]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Shanghai Inst Technol, Sch Mat Sci & Engn, Shanghai 201499, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat CAS, Shanghai 200050, Peoples R China 3.Shanghai Univ, Shanghai Innovat Inst Mat, Shanghai 200444, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Lei,Shao, Yiran,Chang, Chengkang,et al. Efficient Active Oxygen Free Radical Generated in Tumor Cell by Loading-(HCONH2)center dot H2O2 Delivery Nanosystem with Soft-X-ray Radiotherapy[J]. MATERIALS,2018,11(4). |
| APA | Xu, Lei,Shao, Yiran,Chang, Chengkang,&Zhu, Yingchun.(2018).Efficient Active Oxygen Free Radical Generated in Tumor Cell by Loading-(HCONH2)center dot H2O2 Delivery Nanosystem with Soft-X-ray Radiotherapy.MATERIALS,11(4). |
| MLA | Xu, Lei,et al."Efficient Active Oxygen Free Radical Generated in Tumor Cell by Loading-(HCONH2)center dot H2O2 Delivery Nanosystem with Soft-X-ray Radiotherapy".MATERIALS 11.4(2018). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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