Cytocompatibility and Bone-Formation Potential of Se-Coated 316L Stainless Steel with Nano-Pit Arrays
文献类型：期刊论文
| 作者 | Hu, Haoran; Cui, Ran1; Mei, Lin1; Ni, Shirong2; Sun, Hui; Zhang, Changqing; Ni, Siyu1,3 |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 14期号:4页码:716 |
| 关键词 | Stainless Steel Nanotechnology Se Coating Biocompatibility Bone Formation |
| ISSN号 | 1550-7033 |
| DOI | 10.1166/jbn.2018.2526 |
| 英文摘要 | 316L stainless steel is still widely applied in joint replacement and orthopedic surgery due to its mechanical properties, corrosion resistance and relatively low price. In this study, electrochemical oxidation and nanoscale coating were used to fabricate Se-coated 316L stainless steel with nano-pit arrays to enhance its surface characteristics, biocompatibility and osseointegration ability. The modified 316L stainless steel was tested via field emission scanning microscopy (FESEM), energy-dispersive X-ray spectrometry (EDS), X-ray photoelectron spectroscopy (XPS) and Se release studies. The results of this study showed that the nano-pit arrays were 50 nm in diameter and that the Se coating consisted primarily of elemental Se and exhibited sustained release. The biological response of the samples was evaluated using in vitro rat bone marrow mesenchymal stem cell (rBMSCs) experiments and in vivo animal experiments. The modified 316L stainless steel displays enhanced abilities of cell adhesion, proliferation and osteogenic activity, as shown by FESEM, CCK-8 assay, immunofluorescence microscopy (IF) and alkaline phosphatase (ALP) activity assay in vitro and additional new bone formation in vivo, indicating its outstanding cytocompatibility and osteogenic differentiation ability. More importantly, the Se coating can upregulate gene expression of OPN, RUNX-2 and ALP, indicating that the nano-Se-coated 316L stainless steel with nano-pit arrays is a promising biomedical material for implants in orthopedic or dental clinic applications. |
| 学科主题 | Nanoscience & Nanotechnology ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000432853100009 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| 资助机构 | The present study was supported by the National Natural Science Foundation of China (Grant Nos. 81472066 and 81501862) and the Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure (Grant No. SKL201709SIC). ; The present study was supported by the National Natural Science Foundation of China (Grant Nos. 81472066 and 81501862) and the Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure (Grant No. SKL201709SIC). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25023]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Dept Orthoped Surg, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China 2.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China 3.Zhejiang Chinese Med Univ, Dept Pathol, Hangzhou 310053, Zhejiang, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Haoran,Cui, Ran,Mei, Lin,et al. Cytocompatibility and Bone-Formation Potential of Se-Coated 316L Stainless Steel with Nano-Pit Arrays[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018,14(4):716, 724. |
| APA | Hu, Haoran.,Cui, Ran.,Mei, Lin.,Ni, Shirong.,Sun, Hui.,...&Ni, Siyu.(2018).Cytocompatibility and Bone-Formation Potential of Se-Coated 316L Stainless Steel with Nano-Pit Arrays.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,14(4),716. |
| MLA | Hu, Haoran,et al."Cytocompatibility and Bone-Formation Potential of Se-Coated 316L Stainless Steel with Nano-Pit Arrays".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 14.4(2018):716. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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