Copper-Doped Mesoporous Bioactive Glass for Photothermal Enhanced Chemotherapy
文献类型：期刊论文
| 作者 | Chang, Lan1; Liu, Yaqin2; Wu, Chengtie |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 14期号:4页码:786 |
| ISSN号 | 1550-7033 |
| 关键词 | Bone Tumor Mesoporous Bioactive Glass Copper Doxorubicin Hydrochloride Photothermal Effect Combine Therapy |
| DOI | 10.1166/jbn.2018.2542 |
| 英文摘要 | The current therapy for bone tumor is difficult to eliminate tumor cells completely and often leads to bone defects and other side effects. To achieve optimal bone tumor therapeutic effect, a dual functional material with tumor therapy and bone regeneration is required. Herein, we successfully synthesized copper-doped mesoporous bioactive glasses that has both photothermal effect and bone-forming bioactivity. The copper-doped mesoporous bioactive glasses has both excellent drug loading capacity and photothermal property, and the drug release could be well modulated by the photothermal effect. The experiment in vitro showed that copper-doped mesoporous bioactive glasses possessed the ability of a combination of photothermal therapy and chemotherapy to enhance the tumor therapy. In addition, the synthesized copper-doped mesoporous bioactive glasses has good bioactivity for inducing the formation of apatite mineralization. Such dual functional materials present remarkable tumor therapy ability and bone bioactivity, offering new strategy for bone tumor therapy. |
| 学科主题 | Nanoscience & Nanotechnology ; Materials Science, bioMaterials |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| WOS记录号 | WOS:000432853100016 |
| 资助机构 | This work was supported by the Natural Science Foundation of China (5171101275, 81771989), Key Research Program of Frontier Sciences CAS (QYZDB-SSW-SYS027) and Science and Technology Commission of Shanghai Municipality (17441903700, 17540712300). ; This work was supported by the Natural Science Foundation of China (5171101275, 81771989), Key Research Program of Frontier Sciences CAS (QYZDB-SSW-SYS027) and Science and Technology Commission of Shanghai Municipality (17441903700, 17540712300). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25025]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Lan,Liu, Yaqin,Wu, Chengtie. Copper-Doped Mesoporous Bioactive Glass for Photothermal Enhanced Chemotherapy[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018,14(4):786, 794. |
| APA | Chang, Lan,Liu, Yaqin,&Wu, Chengtie.(2018).Copper-Doped Mesoporous Bioactive Glass for Photothermal Enhanced Chemotherapy.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,14(4),786. |
| MLA | Chang, Lan,et al."Copper-Doped Mesoporous Bioactive Glass for Photothermal Enhanced Chemotherapy".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 14.4(2018):786. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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