Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation
文献类型：期刊论文
| 作者 | Zhu, Piao1; Chen, Yu; Shi, Jianlin |
| 刊名 | ACS NANO
 |
| 出版日期 | 2018 |
| 卷号 | 12期号:4页码:3780 |
| 关键词 | sonodynamic therapy protoporphyrin nanoenzyme tumor microenvironment nanomedicine |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b00999 |
| 英文摘要 | Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still not satisfactorily high in combating cancer at the current stage. Here we report on augmenting the SDT efficacy based on catalytic nano medicine, which takes the efficient catalytic features of nanoenzymes to modulate the tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by the integration of a MnO component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed by conjugation with protoporphyrin (as the sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide (as the targeting peptide). The MnO component in the composite nanosonosensitizer acts as an inorganic nanoenzyme for converting the tumor-overexpressed hydrogen peroxide (H2O2) molecules into oxygen and enhancing the tumor oxygen level subsequently, which has been demonstrated to facilitate SDT-induced reactive oxygen species production and enhance SDT efficacy subsequently. The targeted accumulation of these composite nanosonosensitizers efficiently suppressed the growth of U87 tumor xenograft on nude mice after US-triggered SDT treatment. The high in vivo biocompatibility and easy excretion of these multifunctional nanosonosensitizers from the body have also been evaluated and demonstrated to guarantee their future clinical translation, and their TME-responsive T-1-weighted magnetic resonance imaging capability provides the potential for therapeutic guidance and monitoring during SDT. |
| 学科主题 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000431088200075 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51722211 and 51672303), Natural Science Foundation of Shanghai (Grant No. 13ZR1463500), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). ; We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51722211 and 51672303), Natural Science Foundation of Shanghai (Grant No. 13ZR1463500), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25030]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Piao,Chen, Yu,Shi, Jianlin. Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation[J]. ACS NANO,2018,12(4):3780, 3795. |
| APA | Zhu, Piao,Chen, Yu,&Shi, Jianlin.(2018).Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation.ACS NANO,12(4),3780. |
| MLA | Zhu, Piao,et al."Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation".ACS NANO 12.4(2018):3780. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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