Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment
文献类型：期刊论文
| 作者 | Wu, Meiying; Chen, Wenting; Chen, Yu1; Zhang, Haixian; Liu, Chengbo2; Deng, Zhiting; Sheng, Zonghai; Chen, Jingqin2; Liu, Xin; Yan, Fei |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 5期号:4 |
| 关键词 | biodegradable blood brain barrier brain tumor focused ultrasound theranostic |
| ISSN号 | 2198-3844 |
| DOI | 10.1002/advs.201700474 |
| 英文摘要 | The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeutic drugs into orthotopic brain tumor. In this work, a unique theranostic nanoplatform for highly efficient photoacoustic imaging-guided chemotherapy of brain tumor both in vitro and in vivo, which is based on the utilization of hollow mesoporous organosilica nanoparticles (HMONs) to integrate ultrasmall Cu2-xSe particles on the surface and doxorubicin inside the hollow interior, is synthesized. The developed multifunctional theranostic nanosystems exhibit tumor-triggered programmed destruction due to the reducing microenvironment-responsive cleavage of disulfide bonds that are incorporated into the framework of HMONs and linked between HMONs and Cu2-xSe, resulting in tumor-specific biodegradation and on-demand drug-releasing behavior. Such tumor microenvironment-responsive biodegradable and biocompatible theranostic nanosystems in combination with FUS provide a promising delivery nanoplatform with high performance for orthotopic brain tumor imaging and therapy. |
| 学科主题 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000430460200004 |
| 出版者 | WILEY |
| 资助机构 | The authors gratefully acknowledge the support of this research by National Key Basic Research Program of China (973 Program, Grant No. 2015CB755500), National Nature Science Foundation of China (Grant No. 11534013, 81527901), China Postdoctoral Science Foundation (2017M610556), Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province (Grant No. 2014B030301013), Natural Science Foundation of Guangdong Province (Grant No. 2014A030312006, 2016A020213004), and Shenzhen Science and Technology Innovation Committee (Grant No. JCYJ20170307165254568). The authors thank Prof. Zhen Li from Soochow University for the help in synthesizing ultrasmall Cu |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25036]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Paul C Lauterbur Res Ctr Biomed Imaging, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Chinese Acad Sci, Res Lab Biomed Opt & Mol Imaging, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Meiying,Chen, Wenting,Chen, Yu,et al. Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment[J]. ADVANCED SCIENCE,2018,5(4). |
| APA | Wu, Meiying.,Chen, Wenting.,Chen, Yu.,Zhang, Haixian.,Liu, Chengbo.,...&Zheng, Hairong.(2018).Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment.ADVANCED SCIENCE,5(4). |
| MLA | Wu, Meiying,et al."Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment".ADVANCED SCIENCE 5.4(2018). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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