Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing
文献类型：期刊论文
| 作者 | Guo, Jingshu1; Ning, Congqin; Liu, Xuanyong |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2018 |
| 卷号 | 164页码:388 |
| 关键词 | Calcium phosphate silicate coating PLGA Surface modification Tendon-to-bone healing Electron beam evaporation |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2018.02.001 |
| 英文摘要 | Due to the dissimilar features between the tendon and bone, tendon to bone healing is the most challenging problems in sports medicine. In the present work, a novel bioactive calcium phosphate silicate ceramic (CPS) was coated on the surface of PLGA films using electron beam evaporation (EBE) technique to prepare a tailorable composite film with layered chemical composition similar to tendon-bone interface. The physicochemical behaviors of the CPS-PLGA composite films were characterized and the cytocompatibility were also investigated. It was found that the CPS-modified samples exhibited a significantly improved hydrophilicity and a more negative zeta potential. Cell culture results showed that the CPS-modified samples were beneficial to the attachment and proliferation of rBMSCs and NIH3T3 cells. CPS-modified samples also showed an improved osteogenic activity. The results suggested that CPS-modified PLGA films have great potentials for tendon-bone healing. (C) 2018 Elsevier B.V. All rights reserved. |
| 学科主题 | Biophysics ; Chemistry, Physical ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000429762100045 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | The authors are grateful to the financial supports from National Science Foundation for Distinguished Young Scholars of China (51525207) and National Natural Science foundation of China (51672304). ; The authors are grateful to the financial supports from National Science Foundation for Distinguished Young Scholars of China (51525207) and National Natural Science foundation of China (51672304). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25039]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Jingshu,Ning, Congqin,Liu, Xuanyong. Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,164:388, 395. |
| APA | Guo, Jingshu,Ning, Congqin,&Liu, Xuanyong.(2018).Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing.COLLOIDS AND SURFACES B-BIOINTERFACES,164,388. |
| MLA | Guo, Jingshu,et al."Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing".COLLOIDS AND SURFACES B-BIOINTERFACES 164(2018):388. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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