Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1
文献类型：期刊论文
| 作者 | You, Xiebo; Shen, Yueqin1; Yu, Weihan; He, Yaohua |
| 刊名 | MOLECULAR MEDICINE REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 17期号:4页码:4981 |
| 关键词 | hydroxyapatite transforming growth factor 1 rotator cuff tear tendon-bone healing |
| ISSN号 | 1791-2997 |
| DOI | 10.3892/mmr.2018.8499 |
| 英文摘要 | The formation of fibrocartilage at the healing site following a rotator cuff tear repair is a major problem in the field of tendon-bone healing. The present study aimed to enhance the healing of the tendon-bone interface following rotator-cuff tear repair by the interposition of hydroxyapatite (HA) encapsulated with transforming growth factor 1 (TGF1). Using an acute rotator cuff repair model, rats were divided into three groups: i) Repair only (control); ii) HA group; and iii) HA-TGF1 group. Animals were sacrificed at 2, 4 and 8 weeks following surgery. Micro-computed tomography (CT), histomorphometric analyses and biomechanical tests were used to evaluate the supraspinatus tendon-bone complex. The micro-CT images revealed notable novel bone formation in the groups treated with HA-TGF1. The histomorphometric analyses demonstrated improved fibrocartilage formation and collagen organization at the tendon-bone interface. The HA-TGF1 combination significantly improved the area of fibrocartilage, particularly at early time points (2 and 4 weeks). There was a significantly greater load-to-failure force achieved in the HA and HA-TGF1 groups compared with the control group at 4 and 8 weeks. Augmentation of the ceramic powder with HA-TGF1 at the tendon-bone interface was demonstrated to strengthen the healing entheses, increase bone and fibrocartilage formation and improve collagen organization compared with surgical repair alone. Local application of HA-TGF1 demonstrates potential in improving tendon-bone healing following rotator cuff repair. |
| 学科主题 | Oncology ; Medicine, Research & Experimental |
| WOS记录号 | WOS:000428672100015 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | Financial support from the National Natural Science Foundation of China (grant nos. 81271961 and 81572106) is gratefully acknowledged. ; Financial support from the National Natural Science Foundation of China (grant nos. 81271961 and 81572106) is gratefully acknowledged. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25042]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Dept Orthoped, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | You, Xiebo,Shen, Yueqin,Yu, Weihan,et al. Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1[J]. MOLECULAR MEDICINE REPORTS,2018,17(4):4981, 4988. |
| APA | You, Xiebo,Shen, Yueqin,Yu, Weihan,&He, Yaohua.(2018).Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1.MOLECULAR MEDICINE REPORTS,17(4),4981. |
| MLA | You, Xiebo,et al."Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1".MOLECULAR MEDICINE REPORTS 17.4(2018):4981. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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