Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery
文献类型：期刊论文
| 作者 | Yu, Luodan1; Chen, Yu; Lin, Han1; Du, Wenxian1; Chen, Hangrong; Shi, Jianlin |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 161页码:292 |
| 关键词 | Mesoporous organosilica Reduction-responsive biodegradation Drug delivery Nanomedicine Cancer therapy |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2018.01.046 |
| 英文摘要 | Beyond mesoporous silica nanoparticles (MSNs), mesoporous organosilica nanoparticles (MONs) have been becoming an even more attractive alternative to the traditional organic or inorganic nanomaterials in biomedical applications, especially for drug delivery, due to its high surface area, stable physicochemical properties, low toxicity, high biocompatibility, and particularly the devisable features decided by the incorporated organic fragments. However, it is still challenging to fabricate uniform ultrasmall MONs with tunable composition, morphology and fine biodegradability. Herein, we report, on the large-scale fabrication of monodispersed and molecularly organic-inorganic hybrid MON5 with framework incorporated physiologically active thioether bonds, controllable nanostructure, composition and morphology, which provides the material foundation for exploring the versatile biomedical applications of organosilica nanosystems. The hybrid MONs of less than 50 nm in particle size exhibit the unique reduction-responsive biodegradation behavior, and the biodegradation rate is significantly higher than that of traditional mesoporous silica nanoparticles with pure inorganic Si-O-Si framework. The reductive microenvironment-triggered biodegradation of MONs induces the concurrent reduction responsive anticancer drug releasing from MONs, enabling tumor-specific drug delivery. Importantly, these biocompatible and biodegradable MONs exhibit significantly improved drug-delivery efficiency and enhanced tumor-suppressing effect for combating cancer. Based on the facile and large-scale fabrication of MONs with controllable key structure/composition/morphology parameters, unique tumor microenvironment-responsive biodegradation behavior and high performance for drug delivery, the MONs therefore show more promising potentials for clinical translation as compared to traditional MSNs. (C) 2018 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000427100300025 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | We greatly acknowledge the financial support from the National Key Research and Development Program of China (Grant No. 2016YFA0203700, 2017YFB0702602), National Natural Science Foundation of China (Grant No. 51722211, 51672303), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169). ; We greatly acknowledge the financial support from the National Key Research and Development Program of China (Grant No. 2016YFA0203700, 2017YFB0702602), National Natural Science Foundation of China (Grant No. 51722211, 51672303), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25053]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Luodan,Chen, Yu,Lin, Han,et al. Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery[J]. BIOMATERIALS,2018,161:292, 305. |
| APA | Yu, Luodan,Chen, Yu,Lin, Han,Du, Wenxian,Chen, Hangrong,&Shi, Jianlin.(2018).Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery.BIOMATERIALS,161,292. |
| MLA | Yu, Luodan,et al."Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery".BIOMATERIALS 161(2018):292. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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