A bifunctional scaffold with CuFeSe2 nanocrystals for tumor therapy and bone reconstruction
文献类型：期刊论文
| 作者 | Dang, Wentao1; Li, Tao2; Li, Bo; Ma, Hongshi1; Zhai, Dong; Wang, Xiaocheng1; Chang, Jiang; Xiao, Yin3; Wang, Jinwu2; Wu, Chengtie |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 160页码:92 |
| 关键词 | Scaffolds CuFeSe2 Tumor therapy Bone reconstruction |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2017.11.020 |
| 英文摘要 | Bone tumor is one of major challenging issues clinically. After surgical intervention, a few bone tumor cells still remain around bone defects and then proliferate over days. Fabrication of specific biomaterials with dual functions of bone tumor therapy and bone regeneration is of great significance. In order to achieve this aim, we managed to prepare bioactive glass (BG) scaffolds functionalized by the CuFeSe2 nanocrystals (BG-CFS) by combining 3D printing technique with solvothermal method. During the solvothermal reaction process, CuFeSe2 nanocrystals could in situ grow on the strut surface of BG scaffolds and thus endow BG scaffolds excellent photothermal performance. The photothermal performance of BG-CFS scaffolds could be well regulated through altering the content of CuFeSe2 nanocrystals and laser power density when exposed to the near infrared laser (808 nm). The BG-CFS scaffolds could not only effectively ablate the bone tumor cells (Saos-2 cells) in vitro, but also significantly inhibit bone tumor growth in vivo. Moreover, BG-CFS scaffolds could stimulate osteogenic gene expressions of rabbit bone marrow stromal cells (rBMSCs) and finally facilitate the formation of new bone in the bone defects. Our study, for the first time, combined the photothermal performance of semiconductor CuFeSe2 nano crystals with the bone-forming activity of bioactive glass scaffolds, which can offer a more extensive horizon for developing novel biomaterials with dual functions of bone tumor therapy and bone regeneration. (C) 2018 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000425573400008 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | This work was supported by the National Key Research and Development Program of China (2016YFB0700803), the Natural Science Foundation of China (51761135103, 81430012, 81601612), Key Research Program of Frontier Sciences CAS (QYZDB-SSW-SYS027) and Science and Technology Commission of Shanghai Municipality (17441903700, 16DZ2260603, 17540712300), and Key Research Program of Science & Technology Support Program of Jiangsu Province (BE2016763) and Shanghai Sailing Program (17YF1421400). ; This work was supported by the National Key Research and Development Program of China (2016YFB0700803), the Natural Science Foundation of China (51761135103, 81430012, 81601612), Key Research Program of Frontier Sciences CAS (QYZDB-SSW-SYS027) and Science and Technology Commission of Shanghai Municipality (17441903700, 16DZ2260603, 17540712300), and Key Research Program of Science & Technology Support Program of Jiangsu Province (BE2016763) and Shanghai Sailing Program (17YF1421400). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25061]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implant,Dept Orthopaed, Shanghai 200011, Peoples R China 4.Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia |
| 推荐引用方式 GB/T 7714 | Dang, Wentao,Li, Tao,Li, Bo,et al. A bifunctional scaffold with CuFeSe2 nanocrystals for tumor therapy and bone reconstruction[J]. BIOMATERIALS,2018,160:92, 106. |
| APA | Dang, Wentao.,Li, Tao.,Li, Bo.,Ma, Hongshi.,Zhai, Dong.,...&Wu, Chengtie.(2018).A bifunctional scaffold with CuFeSe2 nanocrystals for tumor therapy and bone reconstruction.BIOMATERIALS,160,92. |
| MLA | Dang, Wentao,et al."A bifunctional scaffold with CuFeSe2 nanocrystals for tumor therapy and bone reconstruction".BIOMATERIALS 160(2018):92. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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