The degradation and transport mechanism of a Mg-Nd-Zn-Zr stent in rabbit common carotid artery: A 20-month study
文献类型：期刊论文
| 作者 | Zhang, Jian1,2; Li, Haiyan2; Wang, Wu3; Huang, Hua1; Pei, Jia1; Qu, Haiyun4; Yuan, Guangyin1; Li, Yongdong3 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2018 |
| 卷号 | 69页码:372 |
| 关键词 | Mg alloy stent Common carotid artery In vivo degradation Transport mechanism Vessel calcification |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2018.01.018 |
| 英文摘要 | Mg-based stent is a promising candidate of the next generation fully degradable vascular stents. The latest progress includes the CE approval of the Magmaris (R) WE43 based drug eluting stent. However, so far, the long term (more than 1 year implantation) in vivo degradation and the physiological effects caused by the degradation products were still unclear. In this study, a 20 month observation was carried out after the bare Mg-Nd-Zn-Zr (abbr. JDBM) stent prototype was implanted into the common carotid artery of New Zealand white rabbit in order to evaluate its safety, efficacy and especially degradation behavior. The degradation of the main second phase Mg12Nd was also studied. Results showed that the bare JDBM stent had good safety and efficacy with a complete re-endothelialization within 28 days. The JDBM stent struts were mostly replaced in situ by degradation products in 4 month. The important finding was that the volume and Ca concentration of the degradation products decreased in the long term, eliminating the clinicians' concern of possible vessel calcification. In addition, the alloying elements Mg and Zn in the stent could be safely metabolized as continuous enrichment in any of the main organs were not detected although Nd and Zr showed an abrupt increase in spleen and liver after 1 month implantation. Collectively, the long term in vivo results showed the rapid re-endothelialization of JDBM stent and the long term safety of the degradation products, indicating its great potential as the backbone of the fully degradable vascular stent. Statement of significance Mg-based stent is a promising candidate of the next generation fully degradable stents, especially after the recent market launch of one of its kind (Magmaris). However the fundamental question about the long term degradation and metabolic mechanism of Mg-based stent and its degradation products remain unanswered. We implanted our patented Mg-Nd-Zn-Zr bare stent into the common carotid artery of rabbits and conducted a 20 months observation. We found that the Ca containing degradation products could be further degraded in vivo. All the alloying elements showed no continuous enrichment in the main organs of rabbits. These findings eliminate the clinicians' concern of possible vessel calcification and element enrichment after the implantation of Mg alloy based stents to some extent. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| WOS记录号 | WOS:000427334100031 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | This work was supported by the Natural Science Foundation of China (No. 31771024), the 2016"SMC-Chenxing" Talent Program of Shanghai Jiao Tong University (A), the National Key Research and Development Program of China (No. 2016YFC1102400), the Interdisciplinary Program of Shanghai Jiao Tong University (No. YG2015MS11) and the Science and Technology Commission of Shanghai Municipality (No. 17XD1402100). ; This work was supported by the Natural Science Foundation of China (No. 31771024), the 2016"SMC-Chenxing" Talent Program of Shanghai Jiao Tong University (A), the National Key Research and Development Program of China (No. 2016YFC1102400), the Interdisciplinary Program of Shanghai Jiao Tong University (No. YG2015MS11) and the Science and Technology Commission of Shanghai Municipality (No. 17XD1402100). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25092]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Natl Engn Res Ctr Light Alloy Net Forming, Shanghai 200240, Peoples R China 2.Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composite, Shanghai 200240, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Biomed Engn, Med X Res Inst, Shanghai 200030, Peoples R China 4.Shanghai Jiao Tong Univ, Peoples Hosp 6, Inst Diagnost & Intervent Radiol, Shanghai 200233, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jian,Li, Haiyan,Wang, Wu,et al. The degradation and transport mechanism of a Mg-Nd-Zn-Zr stent in rabbit common carotid artery: A 20-month study[J]. ACTA BIOMATERIALIA,2018,69:372, 384. |
| APA | Zhang, Jian.,Li, Haiyan.,Wang, Wu.,Huang, Hua.,Pei, Jia.,...&Li, Yongdong.(2018).The degradation and transport mechanism of a Mg-Nd-Zn-Zr stent in rabbit common carotid artery: A 20-month study.ACTA BIOMATERIALIA,69,372. |
| MLA | Zhang, Jian,et al."The degradation and transport mechanism of a Mg-Nd-Zn-Zr stent in rabbit common carotid artery: A 20-month study".ACTA BIOMATERIALIA 69(2018):372. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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