2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma
文献类型：期刊论文
| 作者 | Yang, Bowen1; Yin, Junhui2; Chen, Yu; Pan, Shanshan; Yao, Heliang; Gao, Youshui2; Shi, Jianlin |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:10 |
| 关键词 | biomineralization black phosphorus osteosarcoma photothermal therapy scaffolds |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201705611 |
| 英文摘要 | With the ever-deeper understanding of nano-bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next-generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D-printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus-driven, calcium-extracted biomineralization of the intra-scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material-guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process. Additionally, a corrugated structure analogous to Haversian canals is found on newborn cranial bone tissue of Sprague-Dawley rats, which may provide much inspiration for the future research of bone-tissue engineering. |
| 学科主题 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| WOS记录号 | WOS:000426720400015 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | B.Y. and J.Y. contributed equally to this work. The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant No. 51722211 and 51672303), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). All of the animal surgical procedures were approved by the Animal Research Committee of Shanghai Sixth People's Hospital, Shanghai Jiaotong University, School of Medicine. ; B.Y. and J.Y. contributed equally to this work. The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant No. 51722211 and 51672303), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). All of the animal surgical procedures were approved by the Animal Research Committee of Shanghai Sixth People's Hospital, Shanghai Jiaotong University, School of Medicine. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25101]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped Surg, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Bowen,Yin, Junhui,Chen, Yu,et al. 2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma[J]. ADVANCED MATERIALS,2018,30(10). |
| APA | Yang, Bowen.,Yin, Junhui.,Chen, Yu.,Pan, Shanshan.,Yao, Heliang.,...&Shi, Jianlin.(2018).2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma.ADVANCED MATERIALS,30(10). |
| MLA | Yang, Bowen,et al."2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma".ADVANCED MATERIALS 30.10(2018). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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