Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor
文献类型：期刊论文
| 作者 | Wang, Ruizhi; Luo, Yu1; Li, Xin2; Ji, Aihua; Guo, Rongfang; Shi, Xiangyang2; Wang, Xiaolin |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:9页码:1342 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c7tb03076b |
| 英文摘要 | The development of an ultrasensitive nanoprobe is regarded as one of the most promising strategies for the precise diagnosis of tumors. Herein, tanespimycin (17-AAG)-modified polyethylenimine-based gold nanoparticles (AuNPs) co-labeled with a gadolinium (Gd) nanoprobe are constructed for targeted dual-mode computed tomography (CT)/magnetic resonance (MR) imaging. The specific binding of tanespimycin to the N-terminal of heat shock protein 90 (HSP90) endows the modified nanoprobes (NPs) with the ability to up-regulate HSP90 tumor cells and to display excellent X-ray attenuation intensity and T-1 MR imaging performance in an orthotopic hepatocellular carcinoma tumor model. Such an ultrasensitive nanoprobe holds enormous promise for highly efficient tumor diagnosis and dual-mode CT/T-1 positive MR imaging. This study develops a novel strategy to prepare a multifunctional nanoprobe via polyethylenimine nanotechnology. Using this strategy, various dual-mode or multimode nanoprobes for diagnosing different cancers may be designed. |
| 学科主题 | Materials Science, bioMaterials |
| WOS记录号 | WOS:000426706900006 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | This research was financially supported by the National Natural Science Foundation of China (51602334, 21273032 and 81371623), the Sino-German Center for Research Promotion (GZ899), and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. ; This research was financially supported by the National Natural Science Foundation of China (51602334, 21273032 and 81371623), the Sino-German Center for Research Promotion (GZ899), and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25106]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Fudan Univ, Shanghai Inst Med Imaging, Zhongshan Hosp, Dept Intervent, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China 3.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ruizhi,Luo, Yu,Li, Xin,et al. Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(9):1342, 1350. |
| APA | Wang, Ruizhi.,Luo, Yu.,Li, Xin.,Ji, Aihua.,Guo, Rongfang.,...&Wang, Xiaolin.(2018).Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor.JOURNAL OF MATERIALS CHEMISTRY B,6(9),1342. |
| MLA | Wang, Ruizhi,et al."Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor".JOURNAL OF MATERIALS CHEMISTRY B 6.9(2018):1342. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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