The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds: Via structural and functional optimization using collagen networks
文献类型：期刊论文
| 作者 | Wang, Jinbing1; Lin, Chucheng2; Gao, Xin3; Zheng, Zhiwei1; Lv, Mimgming1; Sun, Jian1; Zhang, Zhiyong4,5,6 |
| 刊名 | RSC Advances
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:56页码:32304-32316 |
| DOI | 10.1039/c8ra05615c |
| 英文摘要 | Optimal balance between biological activity and mechanical stability should be meticulously considered during scaffold design for bone tissue engineering applications. To fabricate an individualized construct with biomechanical and biological functionality for bone tissue regeneration, a polycaprolactone-collagen (PCL-COL) composite construct was developed through the combination of three-dimensional printing (3-DP) technology and biomimetic collagen matrix incorporation, with a 3-DP PCL framework maintaining the mechanical stability and a porous collagen matrix improving the biological activity. The results indicate that the compressive modulus of the composite constructs increased synergistically (over 40 MPa), providing sufficient mechanical support during new bone formation. On the other hand, the collagen matrix with a micro-porous architecture structurally increased scaffold areas and provided cellular adhesion sites, allowing for the functional construction of a favorable 3D microenvironment for BMSC adhesion, proliferation and extracellular matrix production. Moreover, critical-sized long bone defect (CSD) implantation demonstrated that the optimized composite constructs could promote bone tissue regeneration (5.5-fold) and bone-material osteointegration (4.7-fold), and decrease fibrosis encapsulation, compared to pristine PCL. The results indicate that these biomimetically ornamented PCL-COL constructs exhibit favorable mechanical properties and biological functionality, demonstrating great potential as an effective bone graft substitute for bone defect treatment. Meanwhile, they can also harness the advantages of 3-DP technology and a collagen-based functionalized strategy, facilitating the creation of customized and functional PCL-COL constructs for clinical translation. © 2018 The Royal Society of Chemistry. |
| 出版者 | Royal Society of Chemistry |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25165]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Center for Oral Disease, 639 Zhizaoju Road, Shanghai; 200011, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 3.Department of Oral Implantology, Shanghai Stomatological Hospital, Fu Dan University, 356 Beijing East Road, Shanghai; 200001, China; 4.Shanghai Key Laboratory of Tissue Engineering, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; 5.Translational Research Centre of Regenerative Medicine, D Printing Technologies of Guangzhou Medical University, Third Affiliated Hospital, Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangzhou City, Guangdong Province, China; 6.China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou; 310058, China |
| 推荐引用方式 GB/T 7714 | Wang, Jinbing,Lin, Chucheng,Gao, Xin,et al. The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds: Via structural and functional optimization using collagen networks[J]. RSC Advances,2018,8(56):32304-32316. |
| APA | Wang, Jinbing.,Lin, Chucheng.,Gao, Xin.,Zheng, Zhiwei.,Lv, Mimgming.,...&Zhang, Zhiyong.(2018).The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds: Via structural and functional optimization using collagen networks.RSC Advances,8(56),32304-32316. |
| MLA | Wang, Jinbing,et al."The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds: Via structural and functional optimization using collagen networks".RSC Advances 8.56(2018):32304-32316. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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