Controllable and durable release of BMP-2-loaded 3D porous sulfonated polyetheretherketone (PEEK) for osteogenic activity enhancement
文献类型：期刊论文
| 作者 | Sun, Zhenjie1,2; Ouyang, Liping1,3; Ma, Xiaohan1; Qiao, Yuqin1; Liu, Xuanyong1 |
| 刊名 | Colloids and Surfaces B: Biointerfaces
 |
| 出版日期 | 2018 |
| 卷号 | 171页码:668-674 |
| ISSN号 | 09277765 |
| DOI | 10.1016/j.colsurfb.2018.08.012 |
| 英文摘要 | Polyetheretherketone (PEEK) is ideal for dental and orthopedic applications because its mechanical properties are similar to cortical bones. However, its inherent inert ability hinders its clinical applications. In this work, bone morphogenetic protein-2 (BMP-2) was immobilized onto the sulfonated PEEK (SPEEK) using lyophilization technology. The surface morphologies of the samples were analyzed by field-emission scanning electron microscopy (FE-SEM), and the chemical compositions were analyzed by energy-dispersive X-ray spectrometry (EDS). The release content of BMP-2 of the samples immersed in the PBS (pH = 7.4) was detected by a human BMP-2 ELISA kit. The results indicated that controllable and durable BMP-2 release was accomplished due to the three-dimensional (3D) network of sulfonated PEEK. The in vitro cellular experiments showed that the BMP-2-immobilized samples significantly enhanced the initial adhesion and spreading of rat bone mesenchymal stem cells (rBMSCs). Moreover, the collagen secretion, extracellular matrix mineralization and ALP activity were also improved. Thus, the BMP-2-immobilized samples greatly promoted the osteogenic differentiation of rBMSCs, which revealed that BMP-2 immobilization paves the way for the use of PEEK in clinical applications. © 2018 Elsevier B.V. |
| 出版者 | Elsevier B.V. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25170]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of the Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai; 200234, China; 3.University of Chinese Academy of Science, Beijing; 100049, China |
| 推荐引用方式 GB/T 7714 | Sun, Zhenjie,Ouyang, Liping,Ma, Xiaohan,et al. Controllable and durable release of BMP-2-loaded 3D porous sulfonated polyetheretherketone (PEEK) for osteogenic activity enhancement[J]. Colloids and Surfaces B: Biointerfaces,2018,171:668-674. |
| APA | Sun, Zhenjie,Ouyang, Liping,Ma, Xiaohan,Qiao, Yuqin,&Liu, Xuanyong.(2018).Controllable and durable release of BMP-2-loaded 3D porous sulfonated polyetheretherketone (PEEK) for osteogenic activity enhancement.Colloids and Surfaces B: Biointerfaces,171,668-674. |
| MLA | Sun, Zhenjie,et al."Controllable and durable release of BMP-2-loaded 3D porous sulfonated polyetheretherketone (PEEK) for osteogenic activity enhancement".Colloids and Surfaces B: Biointerfaces 171(2018):668-674. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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