3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration
文献类型：期刊论文
| 作者 | Zhang, Wenjie1; Feng, Chun2; Yang, Guangzheng1; Li, Guanglong1; Ding, Xun1; Wang, Shaoyi3; Dou, Yuandong4; Zhang, Zhiyuan3; Chang, Jiang2; Wu, Chengtie2 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2017 |
| 卷号 | 135页码:85-95 |
| ISSN号 | 01429612 |
| DOI | 10.1016/j.biomaterials.2017.05.005 |
| 英文摘要 | Segmental bone regeneration remains a considerable challenge due to the associated low degree of vascularization. To solve this problem, in this study, hollow-pipe-packed silicate bioceramic (BRT-H) scaffolds are fabricated using a coaxial three-dimensional (3D) printing technique. Based on a modified core/shell printer nozzle and a modulated viscoelastic bioceramic paste, hollow struts with an external diameter of 1 mm and internal dimeter of 500 μm can be directly printed, yielding a compressive strength of the BRT-H scaffolds as high as 26 MPa. Apart from the effects on osteogenesis, the bioactive ions released from the BRT scaffolds can also facilitate angiogenesis via inducing endothelial cell migration. More importantly, the hollow pipes not only significantly promote the rapid infiltration of host blood vessels into the channels but also exhibit great advantages for the delivery of stem cells and growth factors to further enhance tissue regeneration. When used for the regeneration of rabbit radius segmental defects, radiological and histological findings indicate that the BRT-H scaffolds can enhance early vascularization and later bone regeneration and remodeling. Taken together, the hollow pipes and the ionic products from BRT-H scaffolds have a synergistic effect on enhancing vascularized bone regeneration. © 2017 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25371]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Department of Prosthodontics, Oral Bioengineering and Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaoju Road, Shanghai; 200011, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 3.Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaoju Road, Shanghai; 200011, China; 4.Yantai Zhenghai Bio-tech Co., Ltd., No.10 Hengshan Road, Yantai; 264006, China |
| 推荐引用方式 GB/T 7714 | Zhang, Wenjie,Feng, Chun,Yang, Guangzheng,et al. 3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration[J]. Biomaterials,2017,135:85-95. |
| APA | Zhang, Wenjie.,Feng, Chun.,Yang, Guangzheng.,Li, Guanglong.,Ding, Xun.,...&Jiang, Xinquan.(2017).3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration.Biomaterials,135,85-95. |
| MLA | Zhang, Wenjie,et al."3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration".Biomaterials 135(2017):85-95. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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