The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study
文献类型：期刊论文
| 作者 | Ao, Haiyong1,2; Lin, Chucheng3; Nie, Binen4; Yang, Shengbing4; Xie, Youtao2; Wan, Yizao1; Zheng, Xuebin2 |
| 刊名 | RSC Advances
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:42页码:25828-25837 |
| DOI | 10.1039/c6ra27364e |
| 英文摘要 | Type I collagen and hyaluronic acid are both the main components of bone extracellular matrix, and play important roles in regulating a cell's behavior. In this study, the synergistic effects of type I collagen (Col) and hyaluronic acid (HA) on the biological properties of Col/HA-multilayer-modified titanium coatings were investigated. In vitro, the results of human mesenchymal stem cells culture indicated that Col/HA-multilayers-modified titanium coatings (TC-AA(C/H)6) could better improve a cell's adhesion, proliferation, and differentiation, compared with collagen-modified titanium coatings (TC-AAC) and hyaluronic acid-modified titanium coatings (TC-AAH). In vivo, the micro-CT images indicated that bone trabecula around TC-AA(C/H)6were significantly more than with TC-AAC and TC-AAH. The fluorescence micrograph showed more active new bone formation around implants in TC-AA(C/H)6group than in the TC-AAC and TC-AAH groups in the first month. Measurement of the bone-implant contact on the histological sections indicated there was significantly good osteointegration around TC-AA(C/H)6implants than with the other two modified titanium coatings. All of these results demonstrated that there exists favorable synergistic effects of type I collagen and hyaluronic acid. © 2017 The Royal Society of Chemistry. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25405]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.School of Materials Science and Engineering, East China Jiaotong University, Nanchang; 330013, China; 2.Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai; 200050, China; 3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 4.Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200011, China |
| 推荐引用方式 GB/T 7714 | Ao, Haiyong,Lin, Chucheng,Nie, Binen,et al. The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study[J]. RSC Advances,2017,7(42):25828-25837. |
| APA | Ao, Haiyong.,Lin, Chucheng.,Nie, Binen.,Yang, Shengbing.,Xie, Youtao.,...&Zheng, Xuebin.(2017).The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study.RSC Advances,7(42),25828-25837. |
| MLA | Ao, Haiyong,et al."The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study".RSC Advances 7.42(2017):25828-25837. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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