Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent
文献类型：期刊论文
| 作者 | Ni, Dalong1,2,3; Zhang, Jiawen4; Wang, Jing4; Hu, Ping1; Jin, Yingying4; Tang, Zhongmin1,2; Yao, Zhenwei4; Bu, Wenbo1,3; Shi, Jianlin1 |
| 刊名 | ACS Nano
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:4页码:4256-4264 |
| ISSN号 | 19360851 |
| DOI | 10.1021/acsnano.7b01297 |
| 英文摘要 | Gd3+-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate the key parameters in order to obtain high-relaxivity CAs, according to the classic Solomon-Bloembergen-Morgen theory. Herein, a method of controlling oxygen vacancies in inorganic nanosized CAs has been developed for largely accelerated proton relaxation to obtain a high r1value. Such a strategy is verified on oxygen-deficient PEG-NaxGdWO3nanorods, which exhibit a remarkable r1value up to 80 mM-1s-1(at 0.7 T) and a high r1value of 32.1 mM-1s-1on a clinical 3.0 T scanner, offering an excellent blood pool MRI performance at a low dose. Meanwhile, free electrons and/or oxygen-vacancy-induced small polarons can endow PEG-NaxGdWO3nanorods with significant photothermal conversion for MRI-guided photothermal therapy. © 2017 American Chemical Society. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25417]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.University of Chinese Academy of Science, Beijing; 100049, China; 3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China; 4.Department of Radiology, Huashan Hospital, Fudan University, Shanghai; 200040, China |
| 推荐引用方式 GB/T 7714 | Ni, Dalong,Zhang, Jiawen,Wang, Jing,et al. Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent[J]. ACS Nano,2017,11(4):4256-4264. |
| APA | Ni, Dalong.,Zhang, Jiawen.,Wang, Jing.,Hu, Ping.,Jin, Yingying.,...&Shi, Jianlin.(2017).Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent.ACS Nano,11(4),4256-4264. |
| MLA | Ni, Dalong,et al."Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent".ACS Nano 11.4(2017):4256-4264. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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