Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent
文献类型：期刊论文
| 作者 | Shi, Mengchao1,2; Xia, Lunguo3; Chen, Zetao4; Lv, Fang5; Zhu, Huiying1; Wei, Fei4; Han, Shengwei4; Chang, Jiang1,2; Xiao, Yin2,4; Wu, Chengtie1,2 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2017 |
| 卷号 | 144页码:176-187 |
| ISSN号 | 01429612 |
| DOI | 10.1016/j.biomaterials.2017.08.027 |
| 英文摘要 | Although much research has gone into the design of nanomaterials, inflammatory response still impedes the capacity of nanomaterial-induced tissue regeneration. In-situ incorporation of nutrient elements in silica-based biomaterials has emerged as a new option to endow the nanomaterials modulating biological reactions. In this work, europium-doped mesoporous silica nanospheres (Eu-MSNs) were successfully synthesized via a one-pot method. The nanospheres (size of 280–300 nm) possess uniformly spherical morphology and mesoporous structure, and well distributed Eu elements. The nanospheres show distinct fluorescent property at 615 nm for potential bio-labeling. Noticeably, the Eu-MSNs stimulate pro-inflammatory response of macrophages and induce a modulated immune microenvironment, which further activates the osteogenic differentiation of bone marrow stromal cells (BMSCs) as well as angiogenic activity of human umbilical vein endothelial cells (HUVECs). During the process, osteogenesis-related genes (e.g. ALP, OCN, OPN and COL-I) of BMSCs, and angiogenesis-related genes (e.g. CD31, MMP9, VEGFR1/2, and PDGFRα/β) of HUVECs were significantly upregulated by Eu-MSNs modulating immune environment of macrophages. The in vivo study further demonstrated that the Eu-MSNs could not only stimulate osteogenesis by accelerating the new bone formation at critical-sized cranial defect site, but also support the blood vessel formation as well as collagen deposition and re-epithelialization at chronic skin wound sites, showing an improved angiogenesis activity when comparing with MSNs alone. Given the easy handling characteristics and extensive application potential, the results suggest that Eu-MSNs could be used as immunity-modulated osteogenesis/angiogenesis agent for skin and bone regeneration. © 2017 Elsevier Ltd |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25420]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Australia – China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane; Queensland; 4059, Australia; 3.Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai; 200011, China; 4.Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane; Queensland; 4059, Australia; 5.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai; 200241, China |
| 推荐引用方式 GB/T 7714 | Shi, Mengchao,Xia, Lunguo,Chen, Zetao,et al. Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent[J]. Biomaterials,2017,144:176-187. |
| APA | Shi, Mengchao.,Xia, Lunguo.,Chen, Zetao.,Lv, Fang.,Zhu, Huiying.,...&Wu, Chengtie.(2017).Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent.Biomaterials,144,176-187. |
| MLA | Shi, Mengchao,et al."Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent".Biomaterials 144(2017):176-187. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。