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In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails"

文献类型：期刊论文

作者Shang, Tingting1,2; Liu, Jianxin1,2,3; Chen, Yu4; Hu, Zicheng5; Deng, Liming1,2; Ran, Haitao1,2; Li, Pan1,2; Zheng, Yuanyi1,2,6; Wang, Dong7; Wang, Zhigang1,2
刊名PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
出版日期2018-02-01
卷号35期号:2
关键词Nanomedicine Plga Prussian Blue Synergistic Therapy Theranostic
DOI10.1002/ppsc.201700306
文献子类Article
英文摘要The construction of high-performance nanotheranostic agent with Food and Drug Administration (FDA)-approved materials for efficient treatment of breast cancer is still of great challenge. This work reports, for the first time, on the elaborate integration of two FDA-approved materials together to construct a multifunctional core/shell-structured "nanococktail" for cancer theranostics. The biocompatible Prussian blue nanoparticles with high photothermal-conversion performance are coated by poly(lactic-co-glycolic acid) followed by further surface targeting engineering (folic acid conjugation). The anticancer drug paclitaxel is concurrently encapsulated into the nanocarrier with high efficiency and capacity. Especially, these "nanococktails" act as the desirable contrast agents for photoacoustic/magnetic resonance imaging dual-mode diagnostic imaging, providing the potential for guidance and monitoring during the therapeutic process, which has been systematically demonstrated both in vitro and in vivo. Importantly, these "nanococktails" have demonstrated their high performance in synergistic in vivo photothermal therapy and chemotherapy against breast cancer tumor xenograft. This work not only provides a high-performance theranostic "nanococktail" platform for efficient theranostic treatment of cancer but also paves a new way for the integration of various functional moieties together for realizing the specific diagnostic imaging-guided and synergistic cancer therapy.
WOS关键词BLUE NANOPARTICLES OPERATE ; BREAST-CANCER ; PHOTOTHERMAL THERAPY ; GOLD NANOPARTICLES ; CONTRAST AGENT ; TUMOR ; ABLATION ; NANOCRYSTALS ; CHEMOTHERAPY ; TOMOGRAPHY
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000425641100003
资助机构National Nature Science Foundation of China(81401423 ; National Nature Science Foundation of China(81401423 ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing foundation(cstc2014jcyjA10013) ; Chongqing foundation(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; 81227801 ; 81227801 ; 81630047 ; 81630047 ; 31630026 ; 31630026 ; 81371578 ; 81371578 ; 81771845 ; 81771845 ; 81571688) ; 81571688) ; National Nature Science Foundation of China(81401423 ; National Nature Science Foundation of China(81401423 ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing foundation(cstc2014jcyjA10013) ; Chongqing foundation(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; 81227801 ; 81227801 ; 81630047 ; 81630047 ; 31630026 ; 31630026 ; 81371578 ; 81371578 ; 81771845 ; 81771845 ; 81571688) ; 81571688)
源URL[http://ir.sic.ac.cn/handle/331005/24400]  
专题上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位1.Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China
2.Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Ultrasound Dept, Wuhan 430014, Hubei, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China
5.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400010, Peoples R China
6.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai Inst Ultrasound Med, Shanghai 200233, Peoples R China
7.Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing 400010, Peoples R China
推荐引用方式
GB/T 7714		 Shang, Tingting,Liu, Jianxin,Chen, Yu,et al. In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails"[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2018,35(2).
APA Shang, Tingting.,Liu, Jianxin.,Chen, Yu.,Hu, Zicheng.,Deng, Liming.,...&Sun, Yang.(2018).In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,35(2).
MLA Shang, Tingting,et al."In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails"".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 35.2(2018).

入库方式： OAI收割

来源：上海硅酸盐研究所

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