Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells
文献类型：期刊论文
| 作者 | Huang, Haowen1; Liu, Lanfang1; Zhang, Lingyang1; Zhao, Qian1; Zhou, Yuan1; Yuan, Shishan2; Tang, Zilong1; Liu, Xuanyong3 |
| 刊名 | Analytical Chemistry
 |
| 出版日期 | 2017 |
| 卷号 | 89期号:1页码:666-672 |
| ISSN号 | 00032700 |
| DOI | 10.1021/acs.analchem.6b02966 |
| 英文摘要 | Ethylene diamine tetraacetic acid (EDTA) is such a powerful chelating agent that it may form stable complexes with most metal ions, which has wide applications in industry, agriculture, environment, and pharmaceutical technology. Recently, EDTA was found to enhance the photocatalytic property of some materials. Inspired by this fact of EDTA in the photocatalytic role, we further investigated the photocatalytic property of EDTA and found much the same as that of natural horseradish peroxidase (HRP). This significant discovery of peroxidase-like property may extend the applications of conventional EDTA in life science. A novel and colorimetric sensor based on the peroxidase-like EDTA and unique gold nanorods (GNRs) was designed. Under light irradiation, EDTA may catalyze decomposition of hydrogen peroxide and in situ regulate the longitudinal plasmon wavelength (LPW) of GNRs, displaying various color solution as a read-out means. This colorimetric nanosensor has a great potential to develop into a platform to quantitatively determine analytes as long as the specific antibodies against them were available. Biomarkers of different diseases, such as breast cancer and prostate cancer, were detected with high accuracy. Moreover, combined with immunomagnetic separation of circulating tumor cells (CTCs) from blood, a visual read-out for detection of CTCs was established, which has promising applications in clinical diagnosis, environmental monitoring, and food quality control only using naked eyes. © 2016 American Chemical Society. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25456]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Key Laboratory of Theoretical Organic Chemistry and Function Molecule, Ministry of Education, Hunan Provincial University Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan; 411201, China; 2.School of Medicine, Hunan Normal University, Changsha; 410006, China; 3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China |
| 推荐引用方式 GB/T 7714 | Huang, Haowen,Liu, Lanfang,Zhang, Lingyang,et al. Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells[J]. Analytical Chemistry,2017,89(1):666-672. |
| APA | Huang, Haowen.,Liu, Lanfang.,Zhang, Lingyang.,Zhao, Qian.,Zhou, Yuan.,...&Liu, Xuanyong.(2017).Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells.Analytical Chemistry,89(1),666-672. |
| MLA | Huang, Haowen,et al."Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells".Analytical Chemistry 89.1(2017):666-672. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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